Gómez-Garcés J L, Castilla C
Servicio de Microbiología Clínica, Fundación Jiménez Díaz, Madrid.
Enferm Infecc Microbiol Clin. 1992 Aug-Sep;10(7):389-92.
With the use of an in vitro experimental model of enteritis by Salmonella non typhi the efficacy of amoxicillin, cotrimoxazole and ciprofloxacin in the eradication of this fecal pathogen and the prevention of bacteremia was evaluated. Following a fasting period of 48 hours a total of 160 rats were administered 10 UFC of 2 strains of Salmonella non typhi via intragastric tubing. One of the strains was sensitive to amoxycillin and cotrimoxazole (60 rats) and the other strain was resistant to both but was sensitive to ciprofloxacin (100 rats). The antimicrobials were administered 24 hours after the bacterial infection in daily doses for 5 consecutive days. According to the results obtained amoxicillin and cotrimoxazole were ineffective in the eradication of the fecal pathogen indicating an important obstacle in the appearance of bacteremias. To the contrary, ciprofloxacin, even at low doses, eliminated the microorganisms early and demonstrated high efficacy in the prevention of bacteremia in the animals when these results were compared with those of the untreated group.
利用非伤寒沙门氏菌肠炎的体外实验模型，评估了阿莫西林、复方新诺明和环丙沙星在根除这种粪便病原体及预防菌血症方面的疗效。在禁食48小时后，通过胃管给总共160只大鼠施用10个单位的两种非伤寒沙门氏菌菌株。其中一种菌株对阿莫西林和复方新诺明敏感（60只大鼠），另一种菌株对两者均耐药，但对环丙沙星敏感（100只大鼠）。在细菌感染24小时后，连续5天每日给予抗菌药物。根据获得的结果，阿莫西林和复方新诺明在根除粪便病原体方面无效，这表明菌血症出现的一个重要障碍。相反，与未治疗组的结果相比，环丙沙星即使在低剂量下也能早期清除微生物，并在预防动物菌血症方面显示出高效。
