Galinowski A, Barbouche R, Truffinet P, Louzir H, Poirier M F, Bouvet O, Loo H, Avrameas S
Service Hospitalo-Universitaire, Paris V-Cochin University, Sainte-Anne Hospital, France.
Acta Psychiatr Scand. 1992 Mar;85(3):240-2. doi: 10.1111/j.1600-0447.1992.tb08602.x.
Autoantibodies reacting with cell constituents other than antinuclear antibodies have seldom been reported in the literature on schizophrenia. Serum of 41 DSM-III-R schizophrenic patients was examined for the presence of various autoantibodies and compared with that of healthy volunteers (n = 10) and hospitalized controls. Titers of IgG, IgA and IgM autoantibodies directed against actin, tubulin, myosin, DNA, thyroglobulin, elastin, albumin, DNA and trinitrophenyl groups were determined using enzyme immunoassay. IgG and IgA titers were significantly decreased in schizophrenic patients. These results contrast with those obtained with various other autoimmune and nonautoimmune diseases in which titers are either unchanged or increased. A significant increase of various autoantibody levels was observed in the paranoid subgroup of schizophrenics compared with the disorganized subgroup. These autoantibodies possess characteristics similar to those of natural autoantibodies, which seem to play several biological roles.
在精神分裂症的文献中，很少有关于与抗核抗体以外的细胞成分发生反应的自身抗体的报道。检测了41名DSM-III-R精神分裂症患者血清中各种自身抗体的存在情况，并与健康志愿者（n = 10）和住院对照者的血清进行了比较。使用酶免疫测定法测定针对肌动蛋白、微管蛋白、肌球蛋白、DNA、甲状腺球蛋白、弹性蛋白、白蛋白、DNA和三硝基苯基基团的IgG、IgA和IgM自身抗体的滴度。精神分裂症患者的IgG和IgA滴度显著降低。这些结果与在其他各种自身免疫性和非自身免疫性疾病中获得的结果形成对比，在这些疾病中滴度要么不变要么升高。与紊乱型亚组相比，在偏执型精神分裂症亚组中观察到各种自身抗体水平显著升高。这些自身抗体具有与天然自身抗体相似的特征，天然自身抗体似乎发挥多种生物学作用。
