Szczepanska-Sadowska E
Department of Clinical and Applied Physiology, Warsaw Medical Academy, Poland.
Acta Physiol Scand Suppl. 1989;583:79-87.
Studies performed on normotensive (WKY) and spontaneously hypertensive (SHR) rats indicate that SHR are more sensitive to the hypotensive effects of atrial natriuretic peptide (ANP) administered as a bolus and in iv infusion as well as to pressor infusions (but not bolus injections) of vasopressin (VP). Elevation of blood ANP significantly enhanced reflex bradycardia elicited by bolus injections of VP in WKY, having no effect on pressor responsiveness to VP in any of the strains. Infusion of VP markedely enhanced the hypotensive action of ANP in both WKY and SHR, having no effect on reflex tachycardia elicited by ANP. V1 receptor blockade did not significantly influence effects of ANP on blood pressure and HR responses. The results suggest that under certain conditions ANP and VP may interact in blood pressure control and that this interaction is modified in SHR. In studies performed on conscious dogs central application of ANP exerted no effect on VP secretion in euhydrated animals and during iv infusion of hypertonic NaCl, stimulating thirst. A weak suppressing effect was observed in 24-h dehydrated dogs. The physiological role of ANP in inhibition of VP secretion and its relevance to blood pressure control remains to be established.
对正常血压（WKY）大鼠和自发性高血压（SHR）大鼠进行的研究表明，SHR对静脉推注和静脉输注心房利钠肽（ANP）的降压作用以及对血管加压素（VP）的升压输注（但不是推注）更为敏感。血液中ANP的升高显著增强了WKY大鼠静脉推注VP所引发的反射性心动过缓，对任何品系大鼠对VP的升压反应性均无影响。输注VP显著增强了WKY和SHR大鼠中ANP的降压作用，对ANP引发的反射性心动过速无影响。V1受体阻断对ANP对血压和心率反应的影响无显著影响。结果表明，在某些条件下，ANP和VP可能在血压控制中相互作用，且这种相互作用在SHR中有所改变。在对清醒犬进行的研究中，在正常水合动物以及静脉输注高渗氯化钠刺激口渴期间，中枢应用ANP对VP分泌无影响。在24小时脱水犬中观察到微弱的抑制作用。ANP在抑制VP分泌中的生理作用及其与血压控制的相关性仍有待确定。
