通过全局蛋白质网络比对揭示的细菌和酵母中的保守通路。
Conserved pathways within bacteria and yeast as revealed by global protein network alignment.
作者信息
Kelley Brian P, Sharan Roded, Karp Richard M, Sittler Taylor, Root David E, Stockwell Brent R, Ideker Trey
机构信息
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.
出版信息
Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11394-9. doi: 10.1073/pnas.1534710100. Epub 2003 Sep 22.
Abstract
We implement a strategy for aligning two protein-protein interaction networks that combines interaction topology and protein sequence similarity to identify conserved interaction pathways and complexes. Using this approach we show that the protein-protein interaction networks of two distantly related species, Saccharomyces cerevisiae and Helicobacter pylori, harbor a large complement of evolutionarily conserved pathways, and that a large number of pathways appears to have duplicated and specialized within yeast. Analysis of these findings reveals many well characterized interaction pathways as well as many unanticipated pathways, the significance of which is reinforced by their presence in the networks of both species.
摘要
我们实施了一种比对两个蛋白质-蛋白质相互作用网络的策略，该策略结合了相互作用拓扑结构和蛋白质序列相似性，以识别保守的相互作用途径和复合物。使用这种方法，我们表明，两个远缘物种酿酒酵母和幽门螺杆菌的蛋白质-蛋白质相互作用网络包含大量进化上保守的途径，并且大量途径似乎在酵母中发生了复制和特化。对这些发现的分析揭示了许多特征明确的相互作用途径以及许多意想不到的途径，它们在两个物种网络中的存在增强了其重要性。
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