细胞中的蛋白质折叠：分子伴侣hsp 60和TF55-TCP1两个家族的功能
Protein folding in the cell: functions of two families of molecular chaperone, hsp 60 and TF55-TCP1.
作者信息
Horwich A L, Willison K R
机构信息
Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06510.
出版信息
Philos Trans R Soc Lond B Biol Sci. 1993 Mar 29;339(1289):313-25; discussion 325-6. doi: 10.1098/rstb.1993.0030.
Two families of molecular chaperone, the hsp 60-GroEL family and the TF55-TCP1 family, have been discovered in evolutionarily related cellular compartments. A member of one of these families, hsp 60, has been shown to play a global role in polypeptide chain folding in mitochondria. We review here studies of both hsp 60 and other family members, discussing their essential physiological roles and mechanism of action.
在进化相关的细胞区室中发现了两类分子伴侣，即热休克蛋白60（hsp 60）-GroEL家族和TF55-TCP1家族。其中一个家族的成员hsp 60已被证明在线粒体多肽链折叠中发挥全局作用。我们在此综述对hsp 60和其他家族成员的研究，讨论它们重要的生理作用和作用机制。
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