Stepanov R P
Tsitologiia. 1977 Jul;19(7):756-62.
Using cytophotometry, the amount of DNA, total nuclear proteins and of histones were studied in the myocardial cells during days 21--36 of experimental compensatory hypertrophy of the heart (in rats). The enlargement of myocardial nuclei during the cardial hyperfunction was accompanied by accumulation of total nuclear protein, in particular, the histone fraction, without distinct changes in DNA. Analysis of correlations between nuclear proteins and DNA in the myocardial cells allows to reveal a delayed accumulation of histones in the big and gigantic nuclei, with a superfluous increase in non-histone nuclear proteins. In middle-sized nuclei, non-histone proteins have little changes against intensive accumulation of histones.
运用细胞光度学方法，对大鼠实验性心脏代偿性肥大第21至36天心肌细胞中的DNA、总核蛋白及组蛋白含量进行了研究。心脏功能亢进期间心肌细胞核增大，同时伴有总核蛋白尤其是组蛋白部分的积累，而DNA无明显变化。对心肌细胞核蛋白与DNA之间的相关性分析显示，在大核和巨核中组蛋白积累延迟，非组蛋白核蛋白过度增加。在中等大小的核中，非组蛋白在组蛋白大量积累时变化不大。
