Bos Johannes L
Department for Physiological Chemistry and Centre for Biomedical Genetics, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.
Nat Rev Mol Cell Biol. 2003 Sep;4(9):733-8. doi: 10.1038/nrm1197.
Five years ago, Epac--a guanine nucleotide exchange factor for the Ras-like small GTPases Rap1 and Rap2--was found to be a new target of cyclic AMP, which opened up new avenues for cAMP research. Structural analysis of the cAMP-binding domains of Epac2 has identified a unifying mechanism for how cAMP activates proteins, and the design and synthesis of an Epac-specific cAMP analogue has paved the way for future discoveries.
五年前，Epac（一种针对类Ras小GTP酶Rap1和Rap2的鸟嘌呤核苷酸交换因子）被发现是环磷酸腺苷（cAMP）的一个新靶点，这为cAMP研究开辟了新途径。对Epac2的cAMP结合结构域的结构分析确定了cAMP激活蛋白质的统一机制，并且一种Epac特异性cAMP类似物的设计与合成也为未来的发现铺平了道路。
