Azadbakht L, Shakerhosseini R, Atabak S, Jamshidian M, Mehrabi Y, Esmaill-Zadeh A
Department of Human Nutrition, National Nutrition and Food Technology Research Institute, Tehran, I.R. Iran.
Eur J Clin Nutr. 2003 Oct;57(10):1292-4. doi: 10.1038/sj.ejcn.1601688.
Heart and renal diseases are two major problems in diabetic patients. Hyperlipidemia is one of the main risk factors of cardiovascular complications in diabetes. The type of protein consumed also affects the changes in renal blood flow, glomerular resistance and renal function in these patients. Hence, this study was undertaken to show the effect of soy protein consumption on lipid profiles and kidney function of diabetic patients with nephropathy, who attended an educational university hospital as well as a private kidney disease clinic in Tehran.
This crossover randomized clinical trial was conducted on 14 patients who were free of any uncontrolled condition or other renal diseases. The patients were asked to follow a usual nephropathy diet (0.8 g/kg protein, 70% animal and 30% vegetable protein) for 7 weeks. After a washout period of 4 weeks consuming the prestudy diet, subjects were readmitted to repeat the same cycle with a similar diet containing 35% soy protein and 30% vegetable protein. Paired t-test, carryover effect and period effect were used for statistical analysis.
: There were 10 men and four women whose mean (s.d.) of weight was 70.6 (10.3) kg. Significant reductions were seen in total cholesterol (P<0.01), triglyceride (P<0.002) and LDL-c (P<0.04), urinary urea nitrogen and proteinuria (P<0.001) after soy vs animal protein consumption. There were no significant changes in HDL-c, LDL-c/HDL-c levels. We also saw a favorable effect on renal function.
Soy inclusion in the diet can modify the risk factors of heart disease and improve kidney function in these patients.
心脏和肾脏疾病是糖尿病患者面临的两大主要问题。高脂血症是糖尿病心血管并发症的主要危险因素之一。所摄入蛋白质的类型也会影响这些患者肾血流量、肾小球阻力和肾功能的变化。因此，本研究旨在探讨食用大豆蛋白对患有肾病的糖尿病患者血脂谱和肾功能的影响，这些患者来自德黑兰一所教育型大学医院以及一家私立肾病诊所。
本交叉随机临床试验对14名无任何未控制病情或其他肾脏疾病的患者进行。要求患者遵循常规肾病饮食（0.8克/千克蛋白质，70%动物蛋白和30%植物蛋白）7周。在食用研究前饮食4周的洗脱期后，受试者再次入院，重复相同周期，采用含35%大豆蛋白和30%植物蛋白的类似饮食。采用配对t检验、残留效应和周期效应进行统计分析。
有10名男性和4名女性，平均体重为70.6（10.3）千克。与食用动物蛋白相比，食用大豆蛋白后，总胆固醇（P<0.01）、甘油三酯（P<0.002）和低密度脂蛋白胆固醇（P<0.04）、尿尿素氮和蛋白尿（P<0.001）显著降低。高密度脂蛋白胆固醇、低密度脂蛋白胆固醇/高密度脂蛋白胆固醇水平无显著变化。我们还观察到对肾功能有有利影响。
饮食中加入大豆可以改变这些患者的心脏病危险因素并改善肾功能。
