Ristić Medić Danijela, Ristić Vanja, Arsić Aleksandra, Postić Marija, Ristić Gordana, Blazencić Mladenović Vera, Tepsić Jasna
Institute for Medical Research, Laboratory for Nutrition and Metabolism, Dr Subotića 4a, Belgrade, PO Box 102, 11 129 Belgrade, Serbia and Montenegro.
Nutr Metab Cardiovasc Dis. 2006 Sep;16(6):395-404. doi: 10.1016/j.numecd.2005.06.008. Epub 2005 Nov 4.
Hyperlipidemia is one of the major risk factors of cardiovascular complication in diabetes. High intake of soy product has been suggested to prevent cardiovascular disease. The purpose of this study was to evaluate if dietary supplement of soybean D-LeciVita product, rich in polyunsaturated phospholipids (with 12% lecithin, 35% soy protein) affects serum lipids and serum and erythrocyte phospholipid fatty acid composition in type 2 diabetic patients.
Forty-seven patients (men and post-menopausal women) with isolated hypertriglyceridemia (IHTG) and combined hyperlipidemia (CHL), aged 43-70 years, were given 15g of D-LeciVita powder as a water suspension in a single evening dose during the follow-up period of 12 weeks. Patients kept their diabetic diet relatively constant. Treatment was associated with a significant (p < or = 0.001) decrease in serum total cholesterol and triglyceride levels by 12% and 22%, respectively. LDL-cholesterol decreased by 16% and HDL-cholesterol increased by 11% (p < or = 0.001). Our study shows a 27% decrease in LDL-cholesterol (p < or = 0.001) and a 12% increase in HDL-cholesterol (p < or = 0.01) in CHL type 2 diabetic patients. Triglyceride levels decreased in type 2 diabetic patients with IHTG and CHL by 29% and 13%, respectively (p < or = 0.01 and p < or = 0.05). Our results show decrease in SFA and increase in n-6 and n-3 PUFA in serum and erythrocyte phospholipids. SFA decreased and n-3 PUFA increased in serum and erythrocyte phospholipids in IHTG and CHL groups.
The present study indicated that added to a regular diet, soybean D-LeciVita product (combination of soy protein and lecithin) is associated not only with lipid-lowering effects but also with more favorable serum phospholipids fatty acid profile in type 2 diabetic patients with hyperlipidemia.
高脂血症是糖尿病患者发生心血管并发症的主要危险因素之一。有研究表明，大量摄入豆制品有助于预防心血管疾病。本研究旨在评估富含多不饱和磷脂（含有12%卵磷脂、35%大豆蛋白）的大豆D - 卵磷脂产品作为膳食补充剂，对2型糖尿病患者血脂以及血清和红细胞磷脂脂肪酸组成的影响。
47例年龄在43 - 70岁之间的单纯高甘油三酯血症（IHTG）和混合型高脂血症（CHL）患者（男性及绝经后女性），在为期12周的随访期间，每晚服用15克D - 卵磷脂粉末制成的水悬液。患者保持糖尿病饮食相对稳定。治疗后，血清总胆固醇和甘油三酯水平分别显著降低（p≤0.001）12%和22%。低密度脂蛋白胆固醇（LDL - 胆固醇）降低16%，高密度脂蛋白胆固醇（HDL - 胆固醇）升高11%（p≤0.001）。我们的研究显示，2型CHL糖尿病患者的LDL - 胆固醇降低27%（p≤0.001），HDL - 胆固醇升高12%（p≤0.01）。IHTG和CHL的2型糖尿病患者甘油三酯水平分别降低29%和13%（p≤0.01和p≤0.05）。我们的研究结果显示，血清和红细胞磷脂中的饱和脂肪酸（SFA）减少，n - 6和n - 3多不饱和脂肪酸（PUFA）增加。IHTG和CHL组血清和红细胞磷脂中的SFA减少，n - 3 PUFA增加。
本研究表明，在常规饮食基础上添加大豆D - 卵磷脂产品（大豆蛋白和卵磷脂的组合），不仅对2型高脂血症糖尿病患者具有降脂作用，还能使其血清磷脂脂肪酸谱更为有利。
