慢性乙型肝炎患者α干扰素治疗期间自身抗体的诱导产生

Induction of autoantibodies during alpha interferon treatment in chronic hepatitis B.

作者信息

Fattovich G, Betterle C, Brollo L, Giustina G, Pedini B, Alberti A

机构信息

Istituto di Medicina Clinica, Università di Padova, Italy.

出版信息

Arch Virol Suppl. 1992;4:291-3. doi: 10.1007/978-3-7091-5633-9_65.

DOI:10.1007/978-3-7091-5633-9_65

PMID:1450705

Abstract

Thirty-two patients with chronic hepatitis B treated with alpha interferon were tested for 12 different antibodies. Only a minority (18%) of cases developed antinuclear antibodies and none developed clinical signs of autoimmune disease. These data suggest that, at the dose regimen used, interferon therapy of chronic hepatitis B is not associated with triggering of autoimmunity.

摘要

对32例接受α干扰素治疗的慢性乙型肝炎患者检测了12种不同抗体。只有少数病例（18%）出现抗核抗体，且无一例出现自身免疫性疾病的临床症状。这些数据表明，在所用剂量方案下，慢性乙型肝炎的干扰素治疗与自身免疫触发无关。