Garber S J, Wells A U, duBois R M, Hansell D M
Department of Radiology, Royal Brompton National Heart and Lung Hospital, London, UK.
Br J Radiol. 1992 Nov;65(779):983-6. doi: 10.1259/0007-1285-65-779-983.
The aim of this study was to determine the prevalence of enlarged mediastinal lymph nodes in systemic sclerosis (SSc) and relate this to the extent of pulmonary disease and disease activity as judged by high resolution computed tomography (HRCT). The HRCT scans of 78 patients with SSc were reviewed. The extent of lung disease and HRCT pattern were analysed and CT scans examined on soft tissue window settings for evidence of mediastinal lymph node enlargement. Sixty six (85%) patients had evidence of lung involvement on CT. Enlarged mediastinal lymph nodes were present in 21 (32%) patients with lung involvement but in only 1 (8%) patient without. The prevalence of enlarged mediastinal nodes increased with more extensive lung involvement on CT (p < 0.025), but correlated poorly with the type of CT appearance and concurrent erythrocyte sedimentation rate. Mediastinal lymph node enlargement occurs frequently in patients with SSc, particularly if lung involvement is extensive.
本研究的目的是确定系统性硬化症（SSc）患者纵隔淋巴结肿大的患病率，并将其与根据高分辨率计算机断层扫描（HRCT）判断的肺部疾病范围和疾病活动度相关联。对78例SSc患者的HRCT扫描进行了回顾。分析了肺部疾病的范围和HRCT表现，并在软组织窗设置下检查CT扫描以寻找纵隔淋巴结肿大的证据。66例（85%）患者在CT上有肺部受累的证据。21例（32%）肺部受累患者存在纵隔淋巴结肿大，而无肺部受累的患者中只有1例（8%）出现肿大。纵隔淋巴结肿大的患病率随着CT上肺部受累范围的扩大而增加（p<0.025），但与CT表现类型和同时期红细胞沉降率的相关性较差。纵隔淋巴结肿大在SSc患者中经常出现，尤其是肺部受累广泛时。
