Photochemistry of bromouracil containing Z-DNA.

作者信息

Tashiro Ryu, Sugiyama Hiroshi

机构信息

Division of Biofunctional Molecule, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062 Japan.

出版信息

Nucleic Acids Res Suppl. 2003(3):69-70. doi: 10.1093/nass/3.1.69.

DOI:10.1093/nass/3.1.69

PMID:14510384

Abstract

To investigate the mechanism underlying the photoreaction of bromouracil in DNA, a detailed analysis of photoirradiated 5'-d(CGCG(Br)UGCG)-3'/5'-d(C(8MeO)GCAC(m)GCG)-3' was undertaken. We found that rG- and 2-aminoimidazolone-containing octanucleotides are formed efficiently in Z-form DNA. These results suggest that interstrand electron transfer initiates the photoreaction of bromouracil in Z-DNA.

摘要