Miller Jason A, Hennessy Edward J, Marshall Will J, Scialdone Mark A, Nguyen SonBinh T
Northwestern University, Department of Chemistry, 2145 Sheridan Rd., Evanston, Illinois 60208, USA.
J Org Chem. 2003 Oct 3;68(20):7884-6. doi: 10.1021/jo0344079.
trans-Cyclopropyl beta-amino acid derivatives can be synthesized in five steps with excellent enantioselectivities using a chiral (Salen)Ru(II) cyclopropanation catalyst in the key asymmetry-induction step. This facile synthesis proceeds with high overall yield and can be used to prepare a number of carbamate-protected (Cbz and Boc are demonstrated) beta-amino acid derivatives.
反式环丙基β-氨基酸衍生物可以通过五步合成，在关键的不对称诱导步骤中使用手性（Salen）Ru（II）环丙烷化催化剂，具有优异的对映选择性。这种简便的合成方法总产率高，可用于制备多种氨基甲酸酯保护的（展示了Cbz和Boc）β-氨基酸衍生物。
