α,β-环丙基-γ-氨基酸的三组分合成
Three-component synthesis of alpha,beta-cyclopropyl-gamma-amino acids.
作者信息
Wipf Peter, Stephenson Corey R J
机构信息
Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA. pwipf+@pitt.edu
出版信息
Org Lett. 2005 Mar 17;7(6):1137-40. doi: 10.1021/ol0501525.
PMID:15760158
Abstract
[reaction: see text] The multicomponent coupling of alkenylzirconocenes with N-diphenylphosphinoyl imines provides rapid access to functionalized C-cyclopropylalkylamides which have been readily transformed into alpha,beta-cyclopropyl-gamma-amino acids. These novel scaffolds are thus accessible in ca. 8 steps from commercially available alkynes.
摘要
[反应：见正文] 烯基锆茂与N-二苯基膦酰亚胺的多组分偶联反应能够快速合成官能化的C-环丙基烷基酰胺，这些酰胺可轻松转化为α,β-环丙基-γ-氨基酸。因此，从市售炔烃出发，大约经过8步反应即可获得这些新型骨架。
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