Petersen E, Wågberg F, Angquist K-A
Department of Surgery, Umeå University Hospital, Umeå, Sweden.
Eur J Vasc Endovasc Surg. 2003 Oct;26(4):423-8. doi: 10.1016/s1078-5884(03)00178-3.
to test the hypothesis that there is a negative association between serum levels of lipoprotein(a) (Lp(a)) and elastin-derived peptides (EDP) as well as matrix metalloproteinase (MMP)-9 activation in the aneurysm wall in patients with asymptomatic abdominal aortic aneurysms (AAA).
from 30 patients operated for asymptomatic AAAs, preoperative serum samples and AAA biopsies were collected. Lp(a) (mg/L) and EDP (ng/ml) in serum were measured by enzyme linked immunosorbent assays. MMP-9 activity (arbitrary units) in the AAA wall was measured by gelatin zymography and the ratio: active MMP-9/total MMP-9 were calculated.
there was a significant negative correlation (Spearman's rho) between serum levels of Lp(a) and EDP (r= -0.707, p<0.001), as well as the share of activated MMP-9 (r= -0.461, p=0.01) in the AAA wall.
this preliminary study indicate that Lp(a) inhibit elastolysis in asymptomatic AAA.
检验以下假设，即无症状腹主动脉瘤（AAA）患者血清脂蛋白（a）[Lp（a）]水平与弹性蛋白衍生肽（EDP）以及动脉瘤壁中基质金属蛋白酶（MMP）-9激活之间存在负相关。
收集30例接受无症状AAA手术患者的术前血清样本和AAA活检组织。采用酶联免疫吸附测定法测定血清中Lp（a）（mg/L）和EDP（ng/ml）。通过明胶酶谱法测定AAA壁中MMP-9活性（任意单位），并计算活性MMP-9/总MMP-9的比值。
血清Lp（a）水平与EDP之间存在显著负相关（Spearman等级相关系数）（r = -0.707，p < 0.001），AAA壁中活化MMP-9的比例也存在负相关（r = -0.461，p = 0.01）。
这项初步研究表明，Lp（a）在无症状AAA中抑制弹性蛋白溶解。
