腹主动脉瘤中基质金属蛋白酶-2和-9的活性。与大小和破裂的关系。
Activity of matrix metalloproteinase-2 and -9 in abdominal aortic aneurysms. Relation to size and rupture.
作者信息
Petersen E, Gineitis A, Wågberg F, Angquist K A
机构信息
Department of Surgery, Umeå University Hospital, Umeå, Sweden.
出版信息
Eur J Vasc Endovasc Surg. 2000 Nov;20(5):457-61. doi: 10.1053/ejvs.2000.1211.
OBJECTIVES
to investigate the activity of matrix metalloproteinase (MMP)-2 and -9 in asymptomatic abdominal aortic aneurysms (aAAAs) and ruptured abdominal aortic aneurysms (rAAAs).
DESIGN
cross-sectional study.
MATERIALS AND METHODS
MMP-2 and MMP-9 activity was estimated in biopsies from the anterior wall of 60 AAAs using gelatin zymography. There were 20 medium-sized (diameter 5<7 cm) aAAAs, 20 large (>57 cm) aAAAs and 20 rAAAs. MMP activity was quantified using a laser densitometer and expressed as arbitrary units (au).
RESULTS
mean (SEM) MMP-9 activity was significantly lower in large aAAAs (1190 au +/-247) than in rAAAs (2647 au +/-498, p<0.05). There was no difference in MMP-2 activity.
CONCLUSION
High MMP-9 activity in the AAA wall is associated with rupture.
目的
研究基质金属蛋白酶（MMP）-2和-9在无症状腹主动脉瘤（aAAA）和破裂性腹主动脉瘤（rAAA）中的活性。
设计
横断面研究。
材料与方法
采用明胶酶谱法对60例腹主动脉瘤前壁活检组织中的MMP-2和MMP-9活性进行评估。其中有20例中型（直径5<7 cm）aAAA、20例大型（>57 cm）aAAA和20例rAAA。使用激光密度计对MMP活性进行定量，并以任意单位（au）表示。
结果
大型aAAA的平均（SEM）MMP-9活性（1190 au +/-247）显著低于rAAA（2647 au +/-498，p<0.05）。MMP-2活性无差异。
结论
腹主动脉瘤壁中高MMP-9活性与破裂有关。
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