O'Brien Stephen J, Murphy William J
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA.
Science. 2003 Sep 26;301(5641):1854-5. doi: 10.1126/science.1090531.
The genomes of human, mouse, and rat have been sequenced. Now, as O'Brien and Murphy announce in their Perspective, the genome sequence derby is heating up with the addition of dog to the list (Kirkness et al.). As they explain, even though the coverage of the dog genome (1.5x) is lower than that of mouse (8x), there are many valuable insights to be gained from comparing the sequence of dog with those of mouse and human.
人类、小鼠和大鼠的基因组已被测序。如今，正如奥布赖恩和墨菲在他们的“观点”文章中所宣布的，随着狗被列入测序名单，基因组测序竞赛正在升温（柯克尼斯等人）。正如他们所解释的，尽管狗基因组的覆盖度（1.5倍）低于小鼠（8倍），但通过将狗的序列与小鼠和人类的序列进行比较，仍可获得许多有价值的见解。
