Lu Chih-Cherng, Ho Shung-Tai, Wong Chih-Shung, Wang Jhi-Joung, Tsai Chien-Song, Hu Oliver Yao-Pu, Chang Sun-Yran, Lin Chung-Yuan
Department of Anesthesiology, Tri-Service General Hospital/ National Defense Medical Center, No. 161, Section 6, Minchuan E. Road, Taipei, Taiwan.
Pharmacology. 2003 Nov;69(3):132-7. doi: 10.1159/000072665.
We investigated the effect of the inspired isoflurane concentration (C(I)iso) on body uptake by comparing the isoflurane concentration in the pulmonary artery blood (PAiso) and that in the arterial blood (Aiso) in 16 patients undergoing coronary artery bypass grafting surgery during the 1st, hour of isoflurane anesthesia. The patients received standardized anesthetics consisting of fentanyl and thiopental and were then allocated to receive either 1% or 2% C(I)iso (n = 8 in each group). C(I)iso and end-tidal isoflurane concentration (C(E)iso) were measured by infrared analysis, and Aiso and PAiso were analyzed by gas chromatography. The cardiac output was measured by thermodilution by use of a pulmonary artery catheter. The body tissue could be represented by the gradient C(I)iso-C(E)iso or Aiso-PAiso over time, respectively. The 2% inspired isoflurane group had twice the gradients (either C(I)iso-C(E)iso or Aiso-PAiso) than the 1% inspired isoflurance group. Additionally, both C(I)iso-C(E)iso and Aiso-PAiso were nearly constant over the hour of the study. The inspired concentration-dependent and near-constant uptake of isoflurane over time has important implications which enable us to apply the uptake pattern of isoflurane to clinical practice.
我们通过比较16例接受冠状动脉搭桥手术患者在异氟烷麻醉第1小时期间肺动脉血中异氟烷浓度（PAiso）和动脉血中异氟烷浓度（Aiso），研究了吸入异氟烷浓度（C(I)iso）对机体摄取的影响。患者接受由芬太尼和硫喷妥钠组成的标准化麻醉，然后被分配接受1%或2%的C(I)iso（每组n = 8）。通过红外分析测量C(I)iso和呼气末异氟烷浓度（C(E)iso），通过气相色谱分析Aiso和PAiso。使用肺动脉导管通过热稀释法测量心输出量。机体组织可以分别由C(I)iso - C(E)iso或Aiso - PAiso随时间的梯度来表示。吸入2%异氟烷组的梯度（C(I)iso - C(E)iso或Aiso - PAiso）是吸入1%异氟烷组的两倍。此外，在研究的1小时内，C(I)iso - C(E)iso和Aiso - PAiso几乎保持恒定。异氟烷随时间的吸入浓度依赖性和近乎恒定的摄取具有重要意义，这使我们能够将异氟烷的摄取模式应用于临床实践。
