Lu C C, Tsai C S, Ho S T, Chen W Y, Wong C S, Wang J J, Hu O Y P, Lin C Y
Department of Anaesthesiology, Tri-Service General Hospital/National Defense Medical Center, Room 8113, no. 161, Sec. 6, Minchuan E. Road, Taipei, Taiwan.
Anaesthesia. 2003 Oct;58(10):951-6. doi: 10.1046/j.1365-2044.2003.03346.x.
The aim of this study was to investigate the pharmacokinetics of sevoflurane uptake into the brain and body by comparing sevoflurane concentrations in internal jugular-bulb blood (Jsev), arterial blood (Asev) and pulmonary arterial blood (PAsev) over a fixed inspired sevoflurane concentration. Ten patients (aged 51-73 years), undergoing coronary artery bypass grafting surgery were enrolled in this study. They were anaesthetised using a constant 3.5% inspired sevoflurane concentration (CIsev) during the first hour of anaesthesia. During constant volume-controlled ventilation, we measured CIsev and end-tidal sevoflurane (CEsev) using infrared analysis. The sevoflurane concentration in the blood was analysed using gas chromatography, and cardiac output was measured using an Opti-Q pulmonary artery catheter. We found that it took 40 min for the brain concentration to equilibrate with arterial blood (Asev). Both CIsev-CEsev and Asev-PAsev gradients persisted during the study period. There was no further uptake of sevoflurane into the brain after 40 min; however, there was near-constant uptake into the body.
本研究的目的是通过比较在固定吸入七氟醚浓度下颈内静脉球部血液（Jsev）、动脉血（Asev）和肺动脉血（PAsev）中的七氟醚浓度，来研究七氟醚在脑和体内的药代动力学。本研究纳入了10例接受冠状动脉旁路移植手术的患者（年龄51 - 73岁）。在麻醉的第一个小时内，使用恒定的3.5%吸入七氟醚浓度（CIsev）对他们进行麻醉。在恒定容量控制通气期间，我们使用红外分析测量CIsev和呼气末七氟醚（CEsev）。使用气相色谱法分析血液中的七氟醚浓度，并使用Opti-Q肺动脉导管测量心输出量。我们发现脑浓度与动脉血（Asev）达到平衡需要40分钟。在研究期间，CIsev - CEsev和Asev - PAsev梯度持续存在。40分钟后，七氟醚不再进一步摄取入脑；然而，其在体内的摄取近乎恒定。
