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No evidence for DUP25 in patients with panic disorder using a quantitative real-time PCR approach.

作者信息

Schumacher Johannes, Otte Andreas C J, Becker Tim, Sun Yuli, Wienker Thomas F, Wirth Brunhilde, Franke Petra, Abou Jamra Rami, Propping Peter, Deckert Jürgen, Nöthen Markus M, Cichon Sven

机构信息

Institute of Human Genetics, University of Bonn, Wilhelmstrasse 31, 53111 Bonn, Germany.

出版信息

Hum Genet. 2003 Dec;114(1):115-7. doi: 10.1007/s00439-003-1022-5. Epub 2003 Sep 25.

DOI:10.1007/s00439-003-1022-5
PMID:14513359
Abstract

A duplication of chromosome 15q24-q26 (DUP25) has been reported to be associated with anxiety disorders. We tested for the presence of DUP25 in a sample of 50 patients with panic disorder and 50 controls using a quantitative real-time PCR approach. Contrary to the original finding, our results were compatible with the absence of DUP25, and no significant difference could be detected between patients and controls ( P=1.0). Thus, our study does not support the hypothesis of an involvement of DUP25 in panic disorder.

摘要

相似文献

1
No evidence for DUP25 in patients with panic disorder using a quantitative real-time PCR approach.
Hum Genet. 2003 Dec;114(1):115-7. doi: 10.1007/s00439-003-1022-5. Epub 2003 Sep 25.
2
Failure to find DUP25 in patients with anxiety disorders, in control individuals, or in previously reported positive control cell lines.在焦虑症患者、对照个体或先前报道的阳性对照细胞系中均未发现DUP25。
Am J Hum Genet. 2003 Mar;72(3):535-8. doi: 10.1086/367777. Epub 2003 Jan 24.
3
Failure to detect DUP25 in lymphoblastoid cells derived from patients with panic disorder and control individuals representing European and American populations.
Eur J Hum Genet. 2004 Jun;12(6):505-8. doi: 10.1038/sj.ejhg.5201181.
4
A polymorphic genomic duplication on human chromosome 15 is a susceptibility factor for panic and phobic disorders.人类15号染色体上的一个多态性基因组重复是惊恐障碍和恐惧症的一个易感因素。
Cell. 2001 Aug 10;106(3):367-79. doi: 10.1016/s0092-8674(01)00447-0.
5
No association between DUP25 and anxiety disorders.
Am J Med Genet B Neuropsychiatr Genet. 2004 Jul 1;128B(1):80-3. doi: 10.1002/ajmg.b.30037.
6
A multicolor FISH assay does not detect DUP25 in control individuals or in reported positive control cells.多色荧光原位杂交分析在对照个体或报道的阳性对照细胞中未检测到DUP25。
Am J Hum Genet. 2003 May;72(5):1349-52. doi: 10.1086/375168.
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FISH, flexible joints and panic: are anxiety disorders really expressions of instability in the human genome?
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Inverse correlation between SMN1 and SMN2 copy numbers: evidence for gene conversion from SMN2 to SMN1.SMN1与SMN2拷贝数之间的负相关：SMN2向SMN1基因转换的证据。
Eur J Hum Genet. 2003 Sep;11(9):723. doi: 10.1038/sj.ejhg.5201032.
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Genetics of anxiety disorders.焦虑症的遗传学

本文引用的文献

1
A multicolor FISH assay does not detect DUP25 in control individuals or in reported positive control cells.多色荧光原位杂交分析在对照个体或报道的阳性对照细胞中未检测到DUP25。
Am J Hum Genet. 2003 May;72(5):1349-52. doi: 10.1086/375168.
2
Failure to find DUP25 in patients with anxiety disorders, in control individuals, or in previously reported positive control cell lines.在焦虑症患者、对照个体或先前报道的阳性对照细胞系中均未发现DUP25。
Am J Hum Genet. 2003 Mar;72(3):535-8. doi: 10.1086/367777. Epub 2003 Jan 24.
3
Quantitative analyses of SMN1 and SMN2 based on real-time lightCycler PCR: fast and highly reliable carrier testing and prediction of severity of spinal muscular atrophy.
Curr Psychiatry Rep. 2004 Aug;6(4):243-54. doi: 10.1007/s11920-004-0073-1.
基于实时荧光定量PCR的SMN1和SMN2定量分析：脊髓性肌萎缩症携带者的快速、高度可靠检测及严重程度预测
Am J Hum Genet. 2002 Feb;70(2):358-68. doi: 10.1086/338627. Epub 2001 Dec 21.
4
A polymorphic genomic duplication on human chromosome 15 is a susceptibility factor for panic and phobic disorders.人类15号染色体上的一个多态性基因组重复是惊恐障碍和恐惧症的一个易感因素。
Cell. 2001 Aug 10;106(3):367-79. doi: 10.1016/s0092-8674(01)00447-0.
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Neuronal nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4) and panic disorder: an association study.神经元烟碱型乙酰胆碱受体α4亚基（CHRNA4）与惊恐障碍：一项关联研究。
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J Psychiatr Res. 1986;20(4):317-25. doi: 10.1016/0022-3956(86)90034-8.
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The Composite International Diagnostic Interview. An epidemiologic Instrument suitable for use in conjunction with different diagnostic systems and in different cultures.《综合国际诊断访谈》。一种适用于与不同诊断系统结合使用并在不同文化背景下使用的流行病学工具。
Arch Gen Psychiatry. 1988 Dec;45(12):1069-77. doi: 10.1001/archpsyc.1988.01800360017003.