Tabibi Hadi, Imani Hossein, Atabak Shahnaz, Najafi Iraj, Hedayati Mehdi, Rahmani Leila
Department of Clinical Nutrition & Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran
Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
Perit Dial Int. 2016 Mar-Apr;36(2):140-5. doi: 10.3747/pdi.2015.00006. Epub 2015 Oct 16.
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In peritoneal dialysis (PD) patients, one of the major risk factors for cardiovascular disease is lipid abnormalities. This study was designed to investigate the effects of ginger supplementation on serum lipids and lipoproteins in PD patients. ♦
In this randomized, double-blind, placebo-controlled trial, 36 PD patients were randomly assigned to either the ginger or the placebo group. The patients in the ginger group received 1,000 mg ginger daily for 10 weeks, while the placebo group received corresponding placebos. At baseline and at the end of week 10, 7 mL of blood were obtained from each patient after a 12- to 14-hour fast, and serum concentrations of triglyceride, total cholesterol, low density lipoprotein-cholesterol (LDL-C), high density lipoprotein-cholesterol (HDL-C), and lipoprotein (a) [Lp (a)] were measured. ♦
Serum triglyceride concentration decreased significantly up to 15% in the ginger group at the end of week 10 compared with baseline (p < 0.01), and the reduction was significant in comparison with the placebo group (p < 0.05). There were no significant differences between the 2 groups in mean changes of serum total cholesterol, LDL-C, HDL-C, and Lp (a). ♦
This study indicates that daily administration of 1,000 mg ginger reduces serum triglyceride concentration, which is a risk factor for cardiovascular disease, in PD patients.
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在腹膜透析（PD）患者中，心血管疾病的主要危险因素之一是脂质异常。本研究旨在探讨补充生姜对PD患者血脂和脂蛋白的影响。♦
在这项随机、双盲、安慰剂对照试验中，36名PD患者被随机分为生姜组或安慰剂组。生姜组患者每天服用1000毫克生姜，持续10周，而安慰剂组服用相应的安慰剂。在基线时和第10周结束时，每位患者在禁食12至14小时后采集7毫升血液，测量血清甘油三酯、总胆固醇、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）和脂蛋白（a）[Lp（a）]的浓度。♦
与基线相比，生姜组在第10周结束时血清甘油三酯浓度显著降低了15%（p < 0.01），与安慰剂组相比，降低幅度显著（p < 0.05）。两组在血清总胆固醇、LDL-C、HDL-C和Lp（a）的平均变化方面没有显著差异。♦
本研究表明，每天服用1000毫克生姜可降低PD患者血清甘油三酯浓度，而血清甘油三酯浓度是心血管疾病的一个危险因素。
