Smith A J, Bagg J, Ironside J W, Will R G, Scully C
Infection Research Group, Glasgow Dental Hospital & School, 378 Sauchiehall Street, Glasgow G2 3JZ, Scotland, UK.
J Dent Res. 2003 Oct;82(10):769-75. doi: 10.1177/154405910308201002.
Prion diseases have recently emerged as a significant challenge to health-care workers, including those involved in dentistry. Abnormal prion proteins are resistant to complete inactivation by conventional sterilization techniques. In the last decade, a new form of prion disease emerged in the UK, termed "variant CJD", thought to be acquired by consumption of bovine spongiform encephalopathy-contaminated food products. At present, CJD is an invariably fatal disease with no immediate prospect of treatment or vaccination. Of concern with the variant form of CJD, unlike the more classic forms of the disease, is the appearance of significant levels of infectivity outside the central nervous system. This raises concerns for the potential transmission of prion proteins via surgical procedures from individuals in the asymptomatic stage of the disease. This article reviews the existing knowledge base on the nature of prions, their distribution in oral tissues, and the implications for dental treatment.
朊病毒疾病最近已成为医护人员面临的一项重大挑战，包括牙科领域的医护人员。异常朊病毒蛋白对传统消毒技术的完全灭活具有抗性。在过去十年中，英国出现了一种新的朊病毒疾病形式，称为“变异型克雅氏病”，据认为是通过食用受牛海绵状脑病污染的食品而感染的。目前，克雅氏病是一种必然致命的疾病，没有立即进行治疗或接种疫苗的前景。与变异型克雅氏病相关的问题，与该疾病更典型的形式不同，是在中枢神经系统之外出现了大量的传染性。这引发了人们对朊病毒蛋白可能通过手术程序从疾病无症状阶段的个体传播的担忧。本文综述了关于朊病毒的性质、它们在口腔组织中的分布以及对牙科治疗的影响的现有知识库。
