肺结核中DQB1等位基因频率分析：初步报告。
Analysis of DQB1 allele frequencies in pulmonary tuberculosis: preliminary report.
作者信息
Dubaniewicz A, Moszkowska G, Szczerkowska Z, Hoppe A
机构信息
Department of Pathophysiology, Medical University of Gdańsk, Poland.
出版信息
Thorax. 2003 Oct;58(10):890-1. doi: 10.1136/thorax.58.10.890.
BACKGROUND
The human leucocyte antigen (HLA) system plays an important role in the modulation of the immune response. An association between HLA and pulmonary tuberculosis (TB) has been examined in several populations but the results have been inconsistent. The aim of this study was to evaluate the correlation of DQB1 alleles with TB patients and healthy controls in the same ethnic group in Poland.
METHOD
The DQB1 alleles of 38 patients with TB and 58 healthy university staff volunteers were determined by a PCR-SSP low resolution method.
RESULTS
The DQB105 allele occurred more frequently (p adjusted for multiple comparison=0.002, OR=2.84, 95% CI 1.57 to 5.15) and the DQB102 allele occurred less frequently (p=0.01, OR=0.39, 95% CI 0.21 to 0.71) in patients with TB than in controls. The occurrence of DQB1*03,*04,*06 alleles was similar in the two populations.
CONCLUSIONS
The occurrence of specific DQB1 alleles may be linked to susceptibility/resistance to tuberculosis.
背景
人类白细胞抗原（HLA）系统在免疫反应调节中起重要作用。已在多个群体中研究了HLA与肺结核（TB）之间的关联，但结果并不一致。本研究的目的是评估波兰同一民族中DQB1等位基因与肺结核患者及健康对照之间的相关性。
方法
采用PCR-SSP低分辨率方法测定38例肺结核患者和58名健康大学教职工志愿者的DQB1等位基因。
结果
与对照组相比，DQB105等位基因在肺结核患者中出现频率更高（经多重比较校正的p=0.002，OR=2.84，95%CI为1.57至5.15），而DQB102等位基因出现频率更低（p=0.01，OR=0.39，95%CI为0.21至0.71）。DQB1*03、*04、*06等位基因在两组人群中的出现情况相似。
结论
特定DQB1等位基因的出现可能与肺结核的易感性/抗性有关。
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