泰国人 HLA 二类等位基因与肺结核的关联。

Associations of HLA class II alleles with pulmonary tuberculosis in Thais.

作者信息

Vejbaesya S, Chierakul N, Luangtrakool K, Srinak D, Stephens H A F

机构信息

Department of Transfusion Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

出版信息

Eur J Immunogenet. 2002 Oct;29(5):431-4. doi: 10.1046/j.1365-2370.2002.00352.x.

DOI:10.1046/j.1365-2370.2002.00352.x

PMID:12358854

Abstract

Tuberculosis is an important infectious disease in Thailand. Susceptibility to tuberculosis is influenced not only by the environment but also by host genetic factors. In this study, we investigated HLA alleles in 82 patients with tuberculosis from Bangkok and in 160 normal controls. HLA-DRB1, DQA1 and DQB1 genotyping was performed by the PCR-SSO method. The frequency of HLA-DQB10502 was increased in tuberculosis patients compared to the normal controls (P = 0.01, OR = 2.06). In contrast, the frequencies of DQA10601 and DQB10301 were decreased in tuberculosis patients compared to the controls (P = 0.02 and P = 0.01, respectively). Our results suggest that HLA-DQB10502 may be involved in the development of pulmonary tuberculosis, whereas HLA-DQA10601 and DQB10301 may be associated with protection against tuberculosis.

摘要

结核病是泰国一种重要的传染病。对结核病的易感性不仅受环境影响，还受宿主遗传因素影响。在本研究中，我们调查了82名来自曼谷的结核病患者和160名正常对照者的HLA等位基因。采用PCR-SSO方法进行HLA-DRB1、DQA1和DQB1基因分型。与正常对照相比，结核病患者中HLA-DQB10502的频率升高（P = 0.01，OR = 2.06）。相反，与对照相比，结核病患者中DQA10601和DQB10301的频率降低（分别为P = 0.02和P = 0.01）。我们的结果表明，HLA-DQB10502可能参与肺结核的发生发展，而HLA-DQA10601和DQB10301可能与预防结核病有关。