Delgado-Rodríguez M, Mariscal-Ortiz M, Gómez-Ortega A, Martínez-Gallego G, Palma-Pérez S, Sillero-Arenas M, Medina-Cuadros M
Division of Preventive Medicine and Public Health, University of Jaen, Jaen, Spain.
Br J Surg. 2003 Oct;90(10):1287-93. doi: 10.1002/bjs.4186.
Alcohol consumption increases community-acquired infections and affects the immune system. The aim of this report was to analyse whether drinking increases the risk of nosocomial infection.
This was a prospective study of 1505 patients admitted consecutively to a general surgical department. Alcohol consumption was assessed by a structured questionnaire. Postoperative infection was classified using the Centers for Disease Control criteria. Confounding was controlled for by logistic regression analysis, and the results were stratified by gender and drinking pattern.
Most women were light drinkers and no increased risk of postoperative infection was noted. In men, drinking was associated with a lower American Society of Anesthesiologists grade and fewer co-morbidities. Heavy alcohol consumption (more than 108 g/day) in men increased the rate of all-site nosocomial infection (adjusted odds ratio (OR) 2.51, 95 per cent confidence interval (c.i.) 1.06 to 5.96) and the rate of in-hospital surgical-site infection (SSI) (adjusted OR 2.16, 95 per cent c.i. 0.84 to 5.58). An intake of above 72 g/day increased the rate of lower respiratory tract infection (adjusted OR 5.22, 95 per cent c.i. 1.04 to 26.2). Alcohol consumption was not related to the rate of SSI after hospital discharge. When drinking was limited to weekends, there was no relationship with nosocomial infection.
Heavy alcohol consumption increased the risk of nosocomial infection in men who underwent general surgical procedures.
饮酒会增加社区获得性感染并影响免疫系统。本报告的目的是分析饮酒是否会增加医院感染的风险。
这是一项对连续入住普通外科的1505例患者进行的前瞻性研究。通过结构化问卷评估饮酒情况。使用疾病控制中心的标准对术后感染进行分类。通过逻辑回归分析控制混杂因素，并按性别和饮酒模式对结果进行分层。
大多数女性为轻度饮酒者，未发现术后感染风险增加。在男性中，饮酒与较低的美国麻醉医师协会分级和较少的合并症相关。男性大量饮酒（每天超过108克）会增加所有部位医院感染的发生率（调整后的优势比（OR）为2.51，95%置信区间（c.i.）为1.06至5.96）以及住院手术部位感染（SSI）的发生率（调整后的OR为2.16，95%c.i.为0.84至5.58）。每天摄入量超过72克会增加下呼吸道感染的发生率（调整后的OR为5.22，95%c.i.为1.04至26.2）。饮酒与出院后SSI的发生率无关。当饮酒仅限于周末时，与医院感染无关。
大量饮酒会增加接受普通外科手术男性的医院感染风险。
