Miller William L, Narayanan Srihari, Jackson Julie, Bergmanson Jan
University of Houston, College of Optometry, Houston, Texas 77204-2020, USA.
Optometry. 2003 Sep;74(9):576-82.
Conjunctival folds have been reported as incidental findings in routine biomicroscopic examination, especially related to patients with dry eye disease. We compared the number of lower temporal lid-parallel conjunctival folds (LIPCOF) in normal and moderate dry-eyed patients with specific biomicroscopic findings (corneal staining, limbal injection, and bulbar conjunctival injection) and tear osmolality.
Fourteen moderate dry eye subjects (12 female, 2 male; mean age, 43.4 years--range, 23 to 71 years) and eight normal subjects (3 female, 5 male; mean age, 37.25 years--range, 20 to 55 years) participated in this study. Bulbar conjunctival folds were quantified in the temporal aspect of each eye following fluorescein instillation. Tear osmolality was measured with a vapor pressure osmometer.
There was a slight difference in the number of bulbar conjunctival folds between the moderate dry eye group and the normal controls (2.07 +/- 2.16 vs. 2.25 +/- 0.70, p = 0.676). Conjunctival folds were not correlated with any of the above parameters nor were they associated with the age of the subject. However, the study did reveal that tear osmolality (p = 0.005), corneal staining (p = 0.019), and conjunctival bulbar injection (p = 0.016) were significantly higher in the moderate dry eye group of subjects (Mann Whitney U Test). A significant correlation (Spearmans rho) was found between limbal injection (r2 = 0.535, p = 0.01) and comeal staining. Age was only found to be correlated with tear osmolality (r2 = 0.520, p = 0.013).
Although there was a small difference in the number of conjunctival folds between normal and moderate dry eye subjects, they do not appear to be as discriminating as other variables measured in the study. Additionally, age does not affect the number of conjunctival folds.
结膜皱襞在常规生物显微镜检查中被报告为偶然发现，尤其与干眼症患者有关。我们比较了正常和中度干眼症患者下颞侧睑平行结膜皱襞（LIPCOF）的数量，并观察了特定生物显微镜检查结果（角膜染色、角膜缘充血和球结膜充血）及泪液渗透压。
14名中度干眼症受试者（12名女性，2名男性；平均年龄43.4岁，范围23至71岁）和8名正常受试者（3名女性，5名男性；平均年龄37.25岁，范围20至55岁）参与了本研究。在滴入荧光素后，对每只眼睛颞侧的球结膜皱襞进行量化。用蒸气压渗透压计测量泪液渗透压。
中度干眼症组和正常对照组之间球结膜皱襞数量存在轻微差异（2.07±2.16对2.25±0.70，p = 0.676）。结膜皱襞与上述任何参数均无相关性，也与受试者年龄无关。然而，研究确实显示，中度干眼症组受试者的泪液渗透压（p = 0.005）、角膜染色（p = 0.019）和球结膜充血（p = 0.016）显著更高（曼-惠特尼U检验）。角膜缘充血与角膜染色之间存在显著相关性（斯皮尔曼相关系数，r2 = 0.535，p = 0.01）。仅发现年龄与泪液渗透压相关（r2 = 0.520，p = 0.013）。
尽管正常和中度干眼症受试者之间结膜皱襞数量存在微小差异，但它们似乎不像研究中测量的其他变量那样具有鉴别力。此外，年龄不影响结膜皱襞数量。
