Department of Ophthalmology, Semmelweis University, Budapest, Hungary.
Br J Ophthalmol. 2012 Nov;96(11):1380-5. doi: 10.1136/bjophthalmol-2012-301580. Epub 2012 Sep 5.
The study was designed to test the clinical application of the grading of lid-parallel conjunctival folds (LIPCOF) as a diagnostic test for dry eye.
At 12 centres in 11 countries, 272 eyes of 272 dry eye patients (75 men, 197 women) were examined. Their mean age was 52.7±16.2 years. The LIPCOF were graded according to the method of Höh et al. The tear film break-up time (BUT) was measured, and fluorescein staining and the Schirmer 1 test were performed. The subjective symptoms were evaluated by 16 questions.
The LIPCOF score demonstrated significant positive correlations with age, dry eye disease severity and fluorescein staining (r>0.2, p<0.001), and negative correlations with BUT and results of the Schirmer 1 test (r<-0.2, p<0.001). The LIPCOF score exhibited a significant correlation with the overall subjective symptoms (r=0.250, p<0.001). The sensitivity and specificity of LIPCOF grading for discriminating between normal and dry eyes were best with the cut-off between LIPCOF degrees 1 and 2.
The displayed medium sensitivity and specificity, and good positive predictive value of the LIPCOF test support the use of LIPCOF grading as a simple, quick and non-invasive dry eye screening tool.
本研究旨在测试平行睑结膜皱褶分级（LIPCOF）作为干眼症诊断测试的临床应用。
在 11 个国家的 12 个中心，检查了 272 名干眼症患者（75 名男性，197 名女性）的 272 只眼。他们的平均年龄为 52.7±16.2 岁。根据 Höh 等人的方法对 LIPCOF 进行分级。测量泪膜破裂时间（BUT），并进行荧光素染色和 Schirmer 1 试验。通过 16 个问题评估主观症状。
LIPCOF 评分与年龄、干眼症严重程度和荧光素染色呈显著正相关（r>0.2，p<0.001），与 BUT 和 Schirmer 1 试验结果呈显著负相关（r<-0.2，p<0.001）。LIPCOF 评分与总体主观症状显著相关（r=0.250，p<0.001）。LIPCOF 分级区分正常眼和干眼症的最佳截断值为 1 级和 2 级之间。
LIPCOF 试验显示出中等的敏感性和特异性，以及良好的阳性预测值，支持将 LIPCOF 分级作为一种简单、快速和非侵入性的干眼症筛查工具。
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