Foster David A, Xu Lizhong
The Department of Biological Sciences, Hunter College of The City University of New York, New York, NY 10021, USA.
Mol Cancer Res. 2003 Sep;1(11):789-800.
Phospholipase D (PLD) has emerged as a regulator of several critical aspects of cell physiology. PLD, which catalyzes the hydrolysis of phosphatidylcholine (PC) to phosphatidic acid (PA) and choline, is activated in response to stimulators of vesicle transport, endocytosis, exocytosis, cell migration, and mitosis. Dysregulation of these cell biological processes occurs in the development of a variety of human tumors. It has now been observed that there are abnormalities in PLD expression and activity in many human cancers. In this review, evidence is summarized implicating PLD as a critical regulator of cell proliferation, survival signaling, cell transformation, and tumor progression.
磷脂酶D（PLD）已成为细胞生理学多个关键方面的调节因子。PLD催化磷脂酰胆碱（PC）水解为磷脂酸（PA）和胆碱，它在囊泡运输、内吞作用、胞吐作用、细胞迁移和有丝分裂等刺激因素的作用下被激活。这些细胞生物学过程的失调在多种人类肿瘤的发生发展过程中出现。目前已观察到，在许多人类癌症中，PLD的表达和活性存在异常。在本综述中，总结了相关证据，表明PLD是细胞增殖、生存信号传导、细胞转化和肿瘤进展的关键调节因子。
