Martín M I, Goicoechea C, Colado M I, Alfaro M J
Departamento de Farmacologïa, Facultad de Medicina, Universidad Complutense de Madrid, Spain.
Eur J Pharmacol. 1992 Nov 24;224(1):77-82. doi: 10.1016/0014-2999(92)94821-c.
We compared the analgesia induced by intraperitoneally (i.p.) and intracerebroventricularly (i.c.v.) administered salmon-calcitonin (S-CT), using the hot-plate test and the writhing test. The influence of the route of administration on the analgesia induced by morphine was also studied. After i.p. administration the analgesic effect was observed only in the writhing test. When S-CT was administered i.c.v., analgesia was observed in both tests, although it was greater in the writhing test than in the hot-plate test. I.c.v. injected S-CT increased the analgesia of i.p. injected morphine. Our results provide new information about the analgesic effect of S-CT and suggest that central mechanisms are involved.
我们使用热板试验和扭体试验，比较了腹腔内（i.p.）和脑室内（i.c.v.）注射鲑鱼降钙素（S-CT）所诱导的镇痛作用。还研究了给药途径对吗啡诱导的镇痛作用的影响。腹腔内给药后，仅在扭体试验中观察到镇痛效果。当脑室内注射S-CT时，在两种试验中均观察到镇痛作用，尽管在扭体试验中的镇痛作用比热板试验中更强。脑室内注射的S-CT增强了腹腔内注射吗啡的镇痛作用。我们的结果提供了关于S-CT镇痛作用的新信息，并表明其中涉及中枢机制。
