百日咳毒素对分离组织中降钙素 - 阿片样物质相互作用的影响。
Influence of pertussis toxin on the calcitonin-opioid interaction in isolated tissues.
作者信息
Martin M I, Goicoechea C, Ormazábal M J, Alfaro M J
机构信息
Departamento de Farmacologia, Facultad de Medicina, U. Complutense, Madrid, Spain.
出版信息
Br J Pharmacol. 1996 Nov;119(5):804-6. doi: 10.1111/j.1476-5381.1996.tb15743.x.
Abstract
- In order to clarify one of the mechanisms involved in the analgesic effect of calcitonin, we have tested the in vitro modifications induced by calcitonin on the effect of opioids. 2. The inhibition of the contractions induced by opioids or clonidine, in guinea-pig ileum or in mouse vas deferens, were significantly reduced in tissues incubated with pertussis toxin (PTX). When tissues were incubated with PTX and calcitonin, the inhibitory effect was restored. 3. These results suggest that calcitonin is able to potentiate a non-PTX-sensitive mechanism of transduction and support the possibility of involvement of similar G-proteins in the effects of opioid and alpha 2-adrenoceptor agonists.
摘要
- 为了阐明降钙素镇痛作用的相关机制之一，我们测试了降钙素对阿片类药物作用的体外修饰。2. 在豚鼠回肠或小鼠输精管中，阿片类药物或可乐定诱导的收缩抑制在与百日咳毒素（PTX）孵育的组织中显著降低。当组织与PTX和降钙素一起孵育时，抑制作用得以恢复。3. 这些结果表明，降钙素能够增强一种非PTX敏感的转导机制，并支持类似G蛋白参与阿片类药物和α2肾上腺素能受体激动剂作用的可能性。
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本文引用的文献
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mu and delta opioid agonists at low concentrations decrease voltage-dependent K+ currents in F11 neuroblastoma x DRG neuron hybrid cells via cholera toxin-sensitive receptors.低浓度的μ和δ阿片样物质激动剂通过霍乱毒素敏感受体降低F11神经母细胞瘤x背根神经节神经元杂交细胞中的电压依赖性钾电流。
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Cholera toxin and pertussis toxin on opioid- and alpha 2-mediated supraspinal analgesia in mice.霍乱毒素和百日咳毒素对小鼠阿片类和α2介导的脊髓上镇痛作用的影响。
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Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4741-5. doi: 10.1073/pnas.88.11.4741.
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