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1
Influence of pertussis toxin on the calcitonin-opioid interaction in isolated tissues.百日咳毒素对分离组织中降钙素 - 阿片样物质相互作用的影响。
Br J Pharmacol. 1996 Nov;119(5):804-6. doi: 10.1111/j.1476-5381.1996.tb15743.x.
2
Sympathetic denervation-induced changes in G protein expression in enteric neurons of the guinea pig colon.交感神经去神经支配诱导的豚鼠结肠肠神经元中G蛋白表达的变化。
Life Sci. 2002 Sep 13;71(17):1961-73. doi: 10.1016/s0024-3205(02)01961-6.
3
Role of pertussis toxin-sensitive G-proteins in the analgesic and anesthetic actions of alpha 2-adrenergic agonists in the rat.百日咳毒素敏感的G蛋白在大鼠α2肾上腺素能激动剂的镇痛和麻醉作用中的作用
Anesthesiology. 1995 Oct;83(4):816-22. doi: 10.1097/00000542-199510000-00022.
4
The inhibitory effect of opioid and alpha 2-adrenoceptor agonists on cardiac sensory neurones is pertussis toxin-insensitive.阿片类药物和α2-肾上腺素能受体激动剂对心脏感觉神经元的抑制作用对百日咳毒素不敏感。
Eur J Pharmacol. 1992 Jun 17;216(3):445-8. doi: 10.1016/0014-2999(92)90444-9.
5
Effect of pertussis toxin on normorphine-dependence and on acute inhibitory effects of normorphine and clonidine in guinea-pig isolated ileum.百日咳毒素对豚鼠离体回肠中去甲吗啡依赖性以及去甲吗啡和可乐定急性抑制作用的影响。
Br J Pharmacol. 1984 Oct;83(2):326-8. doi: 10.1111/j.1476-5381.1984.tb16491.x.
6
Prejunctional alpha 2-adrenoceptors in mouse atria function through G-proteins which are sensitive to N-ethylmaleimide, but not pertussis toxin.小鼠心房中的节前α2肾上腺素能受体通过对N-乙基马来酰亚胺敏感但对百日咳毒素不敏感的G蛋白发挥作用。
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7
Effect of pertussis toxin on the interaction of azepexole and halothane.百日咳毒素对阿泽哌醇与氟烷相互作用的影响。
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8
Pertussis toxin blocks M2 muscarinic receptor-mediated effects on contraction and cyclic AMP in the guinea pig ileum, but not M3-mediated contractions and phosphoinositide hydrolysis.百日咳毒素可阻断M2毒蕈碱受体介导的对豚鼠回肠收缩和环磷酸腺苷的作用，但不影响M3介导的收缩和磷酸肌醇水解。
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9
Effect of cholera toxin and pertussis toxin on opioid tolerance and dependence in the guinea-pig myenteric plexus.霍乱毒素和百日咳毒素对豚鼠肠肌丛中阿片类药物耐受性和依赖性的影响。
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10
Complex regulation of calcium current in cardiac cells. Dependence on a pertussis toxin-sensitive substrate, adenosine triphosphate, and an alpha 1-adrenoceptor.心脏细胞中钙电流的复杂调节。依赖于百日咳毒素敏感底物、三磷酸腺苷和α1 -肾上腺素能受体。
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本文引用的文献

1
mu and delta opioid agonists at low concentrations decrease voltage-dependent K+ currents in F11 neuroblastoma x DRG neuron hybrid cells via cholera toxin-sensitive receptors.低浓度的μ和δ阿片样物质激动剂通过霍乱毒素敏感受体降低F11神经母细胞瘤x背根神经节神经元杂交细胞中的电压依赖性钾电流。
Brain Res. 1993 Mar 12;605(2):214-20. doi: 10.1016/0006-8993(93)91743-c.
2
In vitro study of the interaction of salmon calcitonin with mu, delta and kappa opioid agonists.鲑鱼降钙素与μ、δ和κ阿片样激动剂相互作用的体外研究。
Naunyn Schmiedebergs Arch Pharmacol. 1993 Mar;347(3):324-8. doi: 10.1007/BF00167452.
3
Inhibition of cholinergic transmission by opiates in ileal myenteric plexus is mediated by kappa receptor. Involvement of regulatory inhibitory G protein and calcium N-channels.阿片类物质对回肠肌间神经丛胆碱能传递的抑制作用由κ受体介导。涉及调节性抑制性G蛋白和钙N通道。
J Pharmacol Exp Ther. 1994 Feb;268(2):965-70.
4
Pertussis toxin blocks the action of morphine, norepinephrine and clonidine on isolated guinea-pig ileum.百日咳毒素可阻断吗啡、去甲肾上腺素和可乐定对离体豚鼠回肠的作用。
Eur J Pharmacol. 1984 May 4;100(3-4):377-80. doi: 10.1016/0014-2999(84)90017-7.
5
Pertussis toxin abolishes the antinociception mediated by opioid receptors in rat spinal cord.百日咳毒素可消除阿片受体介导的大鼠脊髓中的抗伤害感受作用。
Eur J Pharmacol. 1987 Nov 24;144(1):91-5. doi: 10.1016/0014-2999(87)90013-6.
6
Intrathecal porcine calcitonin enhances the release of [Met5]enkephalin-like material from the rat spinal cord.鞘内注射猪降钙素可增强大鼠脊髓中[Met5]脑啡肽样物质的释放。
Eur J Pharmacol. 1989 Sep 13;168(2):201-8. doi: 10.1016/0014-2999(89)90566-9.
7
Cholera toxin and pertussis toxin on opioid- and alpha 2-mediated supraspinal analgesia in mice.霍乱毒素和百日咳毒素对小鼠阿片类和α2介导的脊髓上镇痛作用的影响。
Life Sci. 1991;48(18):1721-7. doi: 10.1016/0024-3205(91)90208-s.
8
Different G proteins mediate the opioid inhibition or enhancement of evoked [5-methionine]enkephalin release.不同的G蛋白介导阿片类物质对诱发的[5-甲硫氨酸]脑啡肽释放的抑制或增强作用。
Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4741-5. doi: 10.1073/pnas.88.11.4741.
9
After GM1 ganglioside treatment of sensory neurons naloxone paradoxically prolongs the action potential but still antagonizes opioid inhibition.在用GM1神经节苷脂处理感觉神经元后，纳洛酮反常地延长了动作电位，但仍拮抗阿片类物质的抑制作用。
J Pharmacol Exp Ther. 1992 Jan;260(1):182-6.
10
Regulation of G proteins by chronic opiate and clonidine treatment in the guinea pig myenteric plexus.长期阿片类药物和可乐定处理对豚鼠肠肌间神经丛中G蛋白的调节作用
J Pharmacol Exp Ther. 1991 Sep;258(3):790-6.

百日咳毒素对分离组织中降钙素 - 阿片样物质相互作用的影响。

Influence of pertussis toxin on the calcitonin-opioid interaction in isolated tissues.

作者信息

Martin M I, Goicoechea C, Ormazábal M J, Alfaro M J

机构信息

Departamento de Farmacologia, Facultad de Medicina, U. Complutense, Madrid, Spain.

出版信息

Br J Pharmacol. 1996 Nov;119(5):804-6. doi: 10.1111/j.1476-5381.1996.tb15743.x.

DOI:10.1111/j.1476-5381.1996.tb15743.x
PMID:8922724
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1915926/
Abstract
  1. In order to clarify one of the mechanisms involved in the analgesic effect of calcitonin, we have tested the in vitro modifications induced by calcitonin on the effect of opioids. 2. The inhibition of the contractions induced by opioids or clonidine, in guinea-pig ileum or in mouse vas deferens, were significantly reduced in tissues incubated with pertussis toxin (PTX). When tissues were incubated with PTX and calcitonin, the inhibitory effect was restored. 3. These results suggest that calcitonin is able to potentiate a non-PTX-sensitive mechanism of transduction and support the possibility of involvement of similar G-proteins in the effects of opioid and alpha 2-adrenoceptor agonists.
摘要
  1. 为了阐明降钙素镇痛作用的相关机制之一，我们测试了降钙素对阿片类药物作用的体外修饰。2. 在豚鼠回肠或小鼠输精管中，阿片类药物或可乐定诱导的收缩抑制在与百日咳毒素（PTX）孵育的组织中显著降低。当组织与PTX和降钙素一起孵育时，抑制作用得以恢复。3. 这些结果表明，降钙素能够增强一种非PTX敏感的转导机制，并支持类似G蛋白参与阿片类药物和α2肾上腺素能受体激动剂作用的可能性。