Yamamoto M, Kumagai F, Tachikawa S, Maeno H
Eur J Pharmacol. 1979 Apr 15;55(2):211-3. doi: 10.1016/0014-2999(79)90395-9.
Intraventricular administration to mice porcine calcitonin (10 U/kg) as well as of morphine (3 microgram/kg) elevated the threshold pressure of stimuli applied to the base of the tail as assessed by squeaking, struggling or biting, all of which were regarded as manifestations of pain sensation in the animals. Pretreatment with an opiate antagonist, levallorphan (30 mg/kg i.p.) showed no influence upon the analgesic effect of calcitonin, though it completely antagonized the effect of morphine. The results suggested that a peptide hormone, calcitonin, exerted its analgesic action in a manner distinct from the narcotic analgesic.
对小鼠脑室内注射猪降钙素（10 U/kg）以及吗啡（3微克/千克），通过动物发出叫声、挣扎或撕咬来评估，可提高施加于尾根部刺激的阈压，所有这些均被视为动物疼痛感觉的表现。用阿片拮抗剂左洛啡烷（30毫克/千克，腹腔注射）预处理对降钙素的镇痛作用无影响，尽管它能完全拮抗吗啡的作用。结果表明，一种肽类激素降钙素以不同于麻醉性镇痛药的方式发挥其镇痛作用。
