Valero G, Luján J A, Hernández Q, De Las Heras M, Pellicer E, Serrano A, Parrilla P
Department of General Surgery, Virgen de la Arrixaca Hospital University, University of Murcia, 30120, El Palmar, Murcia, Spain.
Int J Colorectal Dis. 2003 Nov;18(6):495-9. doi: 10.1007/s00384-003-0520-1. Epub 2003 Jul 15.
Neoadjuvant radiation and chemotherapy in rectal cancer reduces local recurrences and increases the rate of conservative sphincter surgery. However, an increase in postoperative morbidity and mortality has also been observed. This study analyzed the operative difficulty and postoperative complications in patients with this treatment.
Retrospective review of 103 patients with rectal cancer, divided into two groups: group A, 53 patients undergoing preoperative radiotherapy with 45 Gy combined with chemotherapy, and group B, 50 patients with rectal cancer who received surgery after diagnosis. Both groups were homogeneous. The two groups were compared for both technical difficulty, using intraoperative data and rate of complications.
There were no statistically significant differences between the two groups with regard to intraoperative or postoperative data. In group A there were 20 complications in 17 patients (32%) and in group B 22 complications in 19 patients (38%). The rates of perineal wound infection were similar. The percentage of anastomotic leaks was higher in group A. A greater number of anterior resections was performed in group A.
Preoperative radiation and chemotherapy in rectal cancer does not increase postoperative complications and increases the rate of sphincter-preserving surgery.
直肠癌新辅助放疗和化疗可降低局部复发率，并提高保肛手术的比例。然而，术后发病率和死亡率也有所增加。本研究分析了接受该治疗的患者的手术难度和术后并发症。
对103例直肠癌患者进行回顾性研究，分为两组：A组，53例患者接受45 Gy术前放疗联合化疗；B组，50例直肠癌患者确诊后接受手术。两组具有同质性。比较两组的技术难度（使用术中数据）和并发症发生率。
两组在术中或术后数据方面无统计学显著差异。A组17例患者出现20例并发症（32%），B组19例患者出现22例并发症（38%）。会阴伤口感染率相似。A组吻合口漏的百分比更高。A组进行了更多的前切除术。
直肠癌术前放疗和化疗不会增加术后并发症，且提高了保肛手术的比例。
