Zierden E, Wagner H, Hauss W H
Aktuelle Gerontol. 1976 Feb;6(2):47-51.
82 male rats of different age have been investigated after a definitive run-training, after a run-training with subsequent run-stress and after a run-stress without run-training. An intravenous glucose tolerance test has been done measuring glucose and insulin serum levels before and after i.v. glucose application. Data obtained in this study demonstrate that: 1. adult rats have a better glucose assimilation and higher insulin serum levels after i.v. glucose than older ones. 2. run-stress leads to a deterioration of glucose assimilation and diminution of insulin release in rats of any age. 3. run-training improves glucose tolerance and saves insulin at the same time. 4. in old rats, which have never done any training before, run-training improves glucose assimilation, too. 5. run-stress after run-training has a different effect on adult and old rats: In adult rats there is nearly no effect on glucose assimilation and insulin release in comparison to control animals, while old rats show a significant deterioration of glucose assimilation in comparison to control rats of the same age. Obviously the effect of run-training is less distinct in old rats despite of similar running work.
对82只不同年龄的雄性大鼠进行了研究，分别是在进行确定的跑步训练后、进行跑步训练并随后施加跑步应激后以及只施加跑步应激而无跑步训练后。进行了静脉葡萄糖耐量试验，在静脉注射葡萄糖前后测量血清葡萄糖和胰岛素水平。本研究获得的数据表明：1. 成年大鼠静脉注射葡萄糖后比老年大鼠具有更好的葡萄糖同化能力和更高的血清胰岛素水平。2. 跑步应激会导致任何年龄的大鼠葡萄糖同化能力下降和胰岛素释放减少。3. 跑步训练可改善葡萄糖耐量并同时节省胰岛素。4. 在以前从未进行过任何训练的老年大鼠中，跑步训练也能改善葡萄糖同化能力。5. 跑步训练后施加跑步应激对成年大鼠和老年大鼠有不同影响：与对照动物相比，成年大鼠的葡萄糖同化和胰岛素释放几乎没有影响，而老年大鼠与同年龄的对照大鼠相比，葡萄糖同化能力显著下降。显然，尽管跑步运动量相似，但跑步训练对老年大鼠的影响不太明显。
