Zierden E, Baumeister G, Wagner H
Aktuelle Gerontol. 1977 May;7(5):267-71.
Untrained grown-up and old rats with a mild Streptozotocin-diabetes show in i.v. glucose tolerance test a pathological glucose assimilation and diminished insulin secretion in comparison to control rats of the same age after a maximal run-stress. Trained rats show a different behaviour in glucose tolerance test depending on their age and seriousness of diabetes: Glucose tolerance is improved in grown-up rats with a mild diabetes and unchanged in old rats. Six-week run-training causes a significant deterioration of glucose tolerance in rats with a medium seriously Streptozotocin-diabetes and even leads to death of old rats because of decompensated metabolism. Grown-up rats with a mild diabetes stand run-stress after run-training better than the old ones. No animal with a medium seriously diabetes survives maximal run-stress, old rats don't even survive the slowly increasing run-training. - These results confirm the dualistic effect of muscular work. Metabolism of mild diabetes becomes better through muscular exertion the one of medium diabetes gets worse. Therefore a good effect of run-training is measurable only in grown-up rats not in old ones.
与最大负荷跑步应激后同龄的对照大鼠相比，未经训练的成年和老年链脲佐菌素诱导的轻度糖尿病大鼠在静脉葡萄糖耐量试验中表现出病理性葡萄糖同化和胰岛素分泌减少。训练后的大鼠在葡萄糖耐量试验中的表现因年龄和糖尿病严重程度而异：轻度糖尿病成年大鼠的葡萄糖耐量得到改善，老年大鼠则无变化。六周的跑步训练会导致中度链脲佐菌素糖尿病大鼠的葡萄糖耐量显著恶化，甚至会导致老年大鼠因代谢失代偿而死亡。轻度糖尿病成年大鼠在跑步训练后比老年大鼠更能承受跑步应激。没有一只中度严重糖尿病动物能在最大负荷跑步应激中存活，老年大鼠甚至无法承受缓慢增加的跑步训练。——这些结果证实了肌肉运动的双重作用。轻度糖尿病的代谢通过肌肉运动得到改善，中度糖尿病的代谢则恶化。因此，跑步训练的良好效果仅在成年大鼠中可测量，在老年大鼠中则不可测量。
