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泥炭提取物对小鼠睾丸生精上皮的影响。

The influence of peat extract on the seminiferous epithelium of mouse testes.

作者信息

Bartmańska J, Schüetz A

机构信息

Department of Comaparative Anatomy, Wrocław University, Poland.

出版信息

Folia Biol (Krakow). 1992;40(1-2):83-9.

PMID:1451839
Abstract

Because of the interest in the peat extract as a potential therapeutic agent, its effect on the seminiferous epithelium cells was studied. Adult male mice were intraperitoneally injected with peat extract during 34 days. At intervals equal to the duration of the cycle of the seminiferous epithelium (every 8.5 days), gametogenic cells were quantitatively analysed. It was revealed that the peat extract causes a decrease in the production of the A1 spermatogonia, and as a result a decrease in the intensity of spermatogenesis. Besides, in some individuals disturbances of meiosis took place, leading to an increased degeneration of pachytene spermatocytes and formation of diploid spermatids.

摘要

由于泥炭提取物作为一种潜在治疗剂受到关注,因此研究了其对生精上皮细胞的影响。成年雄性小鼠在34天内腹腔注射泥炭提取物。每隔与生精上皮周期持续时间相等的间隔(每8.5天),对配子发生细胞进行定量分析。结果显示,泥炭提取物导致A1精原细胞的产生减少,进而导致精子发生强度降低。此外,在一些个体中发生了减数分裂紊乱,导致粗线期精母细胞的退化增加以及二倍体精子细胞的形成。

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