丙型肝炎病毒感染的自然史。

Natural history of hepatitis C virus infection.

作者信息

Mondelli M U

机构信息

Research Laboratory, Department of Infectious Diseases, San Matteo Polyclinic IRCCS, University of Pavia, Pavia, Italy.

出版信息

J Biol Regul Homeost Agents. 2003 Apr-Jun;17(2):128-32.

PMID:14518710

Abstract

Hepatitis C virus (HCV) is a common transmissible agent responsible for a significant proportion of chronic liver disease, cirrhosis and hepatocellular carcinoma worldwide. The natural history of acute HCV infection is characterized by a high rate of progression to persistent infection. The resulting chronic liver disease is dependent upon a delicate balance of host, viral and environmental factors which may significantly influence its clinical outcome.

摘要

丙型肝炎病毒（HCV）是一种常见的可传播病原体，在全球范围内导致了相当比例的慢性肝病、肝硬化和肝细胞癌。急性HCV感染的自然史特征是进展为持续性感染的比率很高。由此产生的慢性肝病取决于宿主、病毒和环境因素之间的微妙平衡，这些因素可能会显著影响其临床结局。