Maggi F, Fornai C, Tempestini E, Andreoli E, Lanini L, Vatteroni M L, Pistello M, Marchi S, Antonelli G, Bendinelli M
Virology Section and Retrovirus Centre, Department of Experimental Pathology, University of Pisa, Pisa, Italy.
J Biol Regul Homeost Agents. 2003 Apr-Jun;17(2):176-82.
A group of 24 well-characterized patients doubly infected with hepatitis C virus (HCV) and TT virus (TTV) were studied to evaluate whether the loads and number or identity of the genogroups of TTV they carried could affect the response of HCV infection to interferon-alpha (IFN) treatment. The features of HCV infection in the study patients provided a fair representation of the variables that are usually found in considering patients for IFN treatment. The same was true for the features of TTV infection. In particular, plasma loads of TTV varied over a wide range in individual patients, and infection with multiple TTV genogroups was extremely frequent. TTV genogroups 1 and 3 were the most prevalent, followed by genogroups 4 and 5. The HCV response to IFN was evaluated by measuring plasma viraemia at 24 hours and 30 days after initiation of treatment. The results showed that the TTV parameters investigated had little or no impact on the response of HCV to therapy. Due to study design, these results do not exclude that the presence of a concomitant TTV infection can affect how HCV infection responds to treatment. However, they indicate that, should such effects exist, they would be independent on load and genetic features of the infecting TTV.
对24例特征明确的丙型肝炎病毒（HCV）和TT病毒（TTV）双重感染患者进行了研究，以评估他们所携带的TTV基因组的载量、数量或类型是否会影响HCV感染对α干扰素（IFN）治疗的反应。研究患者的HCV感染特征合理地代表了在考虑IFN治疗的患者中通常发现的变量。TTV感染特征也是如此。特别是，个体患者的TTV血浆载量变化范围很广，感染多种TTV基因组的情况极为常见。TTV基因组1和3最为普遍，其次是基因组4和5。通过在治疗开始后24小时和30天测量血浆病毒血症来评估HCV对IFN的反应。结果表明，所研究的TTV参数对HCV治疗反应几乎没有影响。由于研究设计，这些结果并不排除合并TTV感染的存在会影响HCV感染对治疗的反应。然而，它们表明，如果存在这种影响，将独立于感染性TTV的载量和基因特征。
