赫波烯/ GEX 1A的全合成。
Total synthesis of herboxidiene/GEX 1A.
作者信息
Zhang Yun, Panek James S
机构信息
Department of Chemistry and Center for Chemical Methodology and Library Development, Metcalf Center for Science and Engineering, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, USA.
出版信息
Org Lett. 2007 Aug 2;9(16):3141-3. doi: 10.1021/ol701427k. Epub 2007 Jul 13.
Abstract
A convergent enantioselective synthesis of herboxidiene/GEX 1A (1) is described that features a double stereodifferentiating crotylation, [4 + 2] annulation, and a silicon-based sp2-sp2 cross-coupling to assemble the conjugated diene.
摘要
本文描述了一种赫伯烯/ GEX 1A（1）的对映选择性汇聚合成方法，该方法的特点是通过双重立体定向巴豆酰化、[4 + 2]环化以及基于硅的sp2-sp2交叉偶联来构建共轭二烯。
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