分离的小鼠肝细胞中由甲基乙二醛生成葡萄糖的过程。是否存在一条丙酮酸不是中间产物的替代途径？
Gluconeogenesis from methylglyoxal in isolated murine hepatocytes. Does an alternative pathway exist in which pyruvate is not an intermediate?
作者信息
Riba P, Garzó T, Mandl J, Kalapos M P
机构信息
Semmelweis University, Medical School, First Institute of Biochemistry, Budapest, Hungary.
出版信息
Int J Biochem. 1992 Nov;24(11):1721-4. doi: 10.1016/0020-711x(92)90119-l.
PMID:1451907
Abstract
- Gluconeogenesis from alanine can be prevented by the addition of monoiodo acetic acid (an inhibitor of glyceraldehyde 3-phosphate dehydrogenase), while glucose production from methylglyoxal is only partially inhibited by this compound. 2. It is supposed that methylglyoxal can enter gluconeogenic sequence not only at pyruvate.
摘要
- 添加单碘乙酸（甘油醛-3-磷酸脱氢酶的抑制剂）可阻止由丙氨酸生成葡萄糖异生作用，而该化合物仅部分抑制由甲基乙二醛生成葡萄糖的过程。2. 据推测，甲基乙二醛不仅可以在丙酮酸处进入糖异生途径。
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