Nelson Jerusha L, Bernstein Paul S, Schmidt Matthew C, Von Tress Mark S, Askew E Wayne
Division of Foods and Nutrition, University of Utah, Salt Lake City, UT 84115, USA.
J Nutr. 2003 Oct;133(10):3117-23. doi: 10.1093/jn/133.10.3117.
Oxidative stress is thought to be a factor in the progression of chronic diseases, and even the aging process itself. We examined the effect of two moderate vitamin, mineral and phytochemical supplements and a dietary intervention on markers of oxidative stress and antioxidant status in older humans. Subjects (n = 60, 65-85 y old) were enrolled in a 5-wk, double-blind, placebo-controlled study. The subjects were randomly assigned to a group with one of four interventions: antioxidant supplement capsule, antioxidant supplement tablet, high carotenoid diet or placebo. Postintervention serum levels of some of the supplemented carotenoids and alpha-tocopherol were higher in all treated groups compared with the placebo group and with preintervention levels within groups. Markers of oxidative stress or antioxidant capacity were not significantly different from preintervention levels, although the diet and supplement capsule groups had lower levels of some of those markers than the placebo group postintervention. The results suggest that both moderate antioxidant supplementation and a diet high in carotenoids elevate serum carotenoids and antioxidant levels in an older adult population, although with different specific effects.
氧化应激被认为是慢性疾病进展甚至衰老过程本身的一个因素。我们研究了两种适度的维生素、矿物质和植物化学物质补充剂以及一种饮食干预对老年人氧化应激标志物和抗氧化状态的影响。受试者（n = 60，65 - 85岁）参加了一项为期5周的双盲、安慰剂对照研究。受试者被随机分配到四组干预措施之一的组中：抗氧化补充剂胶囊、抗氧化补充剂片剂、高类胡萝卜素饮食或安慰剂。与安慰剂组以及组内干预前水平相比，所有治疗组干预后补充的一些类胡萝卜素和α-生育酚的血清水平更高。氧化应激或抗氧化能力的标志物与干预前水平没有显著差异，尽管饮食和补充剂胶囊组在干预后的一些标志物水平低于安慰剂组。结果表明，适度的抗氧化补充剂和高类胡萝卜素饮食都能提高老年人群的血清类胡萝卜素和抗氧化水平，尽管有不同的具体效果。
