Archer W Roodly, Lamarche Benoît, St-Pierre Annie C, Mauger Jean-François, Dériaz Olivier, Landry Nancy, Corneau Louise, Després Jean-Pierre, Bergeron Jean, Couture Patrick, Bergeron Nathalie
Nutraceuticals and Functional Foods Institute, Laval University, Québec, Canada G1K 7P4.
J Nutr. 2003 Oct;133(10):3124-9. doi: 10.1093/jn/133.10.3124.
We compared the effects of ad libitum consumption of a defined high complex carbohydrate (CHO) diet (% of energy: CHO, 58.3; fat, 25.8) vs. a defined high monounsaturated fatty acid (MUFA) diet (% of energy: CHO, 44.7; fat, 40.1; MUFA, 22.5) on LDL electrophoretic characteristics. Healthy men [n = 65; age, 37.5 +/- 11.2 (mean +/- SD) y; BMI, 29.2 +/- 4.9 kg/m2] were randomly assigned to one of the two diets that they consumed for 6-7 wk. The high CHO diet significantly reduced body weight (-2%). The diet-induced reduction in plasma LDL cholesterol (C) levels in the high-CHO diet group was due mainly to concurrent reductions in the cholesterol content of small (<25.5 nm, P < 0.01) and medium-sized LDL (25.5-26.0 nm, P = 0.01). The high MUFA diet also reduced body weight, and LDL-C and LDL-apolipoprotein (apo)B levels, which were comparable to those in the high CHO group. The cholesterol levels of small LDL particles tended to be reduced (P = 0.24) in the high MUFA group (-12%), similar to changes in the high CHO group. These results suggest that, when associated with weight loss, ad libitum consumption of high CHO and high MUFA diets may be considered to be equally beneficial for the management of LDL-related atherogenic dyslipidemia. However, the high MUFA diet more favorably affected triglyceride levels, suggesting that it may be preferable to a high CHO diet in cardiovascular disease prevention.
我们比较了随意食用特定的高复合碳水化合物（CHO）饮食（能量占比：CHO 58.3%；脂肪 25.8%）与特定的高单不饱和脂肪酸（MUFA）饮食（能量占比：CHO 44.7%；脂肪 40.1%；MUFA 22.5%）对低密度脂蛋白（LDL）电泳特征的影响。健康男性[n = 65；年龄，37.5 ± 11.2（均值 ± 标准差）岁；体重指数（BMI），29.2 ± 4.9 kg/m²]被随机分配至两种饮食中的一种，并食用 6 - 7 周。高 CHO 饮食显著降低了体重（-2%）。高 CHO 饮食组中饮食诱导的血浆 LDL 胆固醇（C）水平降低主要归因于小颗粒（<25.5 nm，P < 0.01）和中等大小 LDL（25.5 - 26.0 nm，P = 0.01）胆固醇含量的同时降低。高 MUFA 饮食也降低了体重、LDL - C 和 LDL - 载脂蛋白（apo）B 水平，与高 CHO 组相当。高 MUFA 组中小 LDL 颗粒的胆固醇水平有降低趋势（P = 0.24）（-12%），与高 CHO 组的变化相似。这些结果表明，在与体重减轻相关时，随意食用高 CHO 和高 MUFA 饮食对于管理与 LDL 相关的致动脉粥样硬化性血脂异常可能同样有益。然而，高 MUFA 饮食对甘油三酯水平的影响更有利，表明在预防心血管疾病方面它可能比高 CHO 饮食更可取。
