Koc Mehmet, Taysi Seyithan, Sezen Orhan, Bakan Nuri
Departments of Radiation Oncology, Ataturk University Medical School, Erzurum, Turkey.
Biol Pharm Bull. 2003 Oct;26(10):1494-7. doi: 10.1248/bpb.26.1494.
The acute phase response involves changes in serum concentrations of a number of liver-synthesized proteins. Among these are C-reactive protein (CRP), ferritin (FER), transferrin (Trf) and ceruloplasmin (Cp). Determination of serum CRP, FER, Trf, and Cp was performed in 52 patients with inoperable head and neck cancer (n=11), inoperable esophageal cancer (n=10), rectal cancer (n=9; operation was performed=5, inoperable=4), and lung cancer (n=22), all of whom were treated with radical radiotherapy (RT). Post-radiotherapy CRP levels were significantly higher compared to the preradiotherapy levels (p<0.001). We found decreased serum Trf levels during the irradiation period, while acute-phase proteins such as CRP, FER, and Cp levels increased during the RT period. Further studies on the roles of other acute phase reactants and the above mentioned parameters in a large-patients-with cancer group during radiotherapy are required to understand the role of markers, which are altered during radiotherapy.
急性期反应涉及多种肝脏合成蛋白的血清浓度变化。其中包括C反应蛋白（CRP）、铁蛋白（FER）、转铁蛋白（Trf）和铜蓝蛋白（Cp）。对52例无法手术的头颈癌患者（n = 11）、无法手术的食管癌患者（n = 10）、直肠癌患者（n = 9；已进行手术 = 5例，无法手术 = 4例）和肺癌患者（n = 22）进行了血清CRP、FER、Trf和Cp的测定，所有患者均接受了根治性放疗（RT）。放疗后CRP水平显著高于放疗前水平（p < 0.001）。我们发现照射期间血清Trf水平降低，而CRP、FER和Cp等急性期蛋白水平在放疗期间升高。需要在大量癌症患者群体中对放疗期间其他急性期反应物和上述参数的作用进行进一步研究，以了解放疗期间发生改变的标志物的作用。
