Zhang Caiguo, Zhang Fan
Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO, 80045, USA,
Protein Cell. 2015 Feb;6(2):88-100. doi: 10.1007/s13238-014-0119-z. Epub 2014 Dec 6.
Excess iron is tightly associated with tumorigenesis in multiple human cancer types through a variety of mechanisms including catalyzing the formation of mutagenic hydroxyl radicals, regulating DNA replication, repair and cell cycle progression, affecting signal transduction in cancer cells, and acting as an essential nutrient for proliferating tumor cells. Thus, multiple therapeutic strategies based on iron deprivation have been developed in cancer therapy. During the past few years, our understanding of genetic association and molecular mechanisms between iron and tumorigenesis has expanded enormously. In this review, we briefly summarize iron homeostasis in mammals, and discuss recent progresses in understanding the aberrant iron metabolism in numerous cancer types, with a focus on studies revealing altered signal transduction in cancer cells.
过量铁通过多种机制与多种人类癌症类型的肿瘤发生紧密相关，这些机制包括催化诱变羟基自由基的形成、调节DNA复制、修复和细胞周期进程、影响癌细胞中的信号转导，以及作为增殖肿瘤细胞的必需营养素。因此，癌症治疗中已开发出多种基于铁剥夺的治疗策略。在过去几年中，我们对铁与肿瘤发生之间的遗传关联和分子机制的理解有了极大的扩展。在这篇综述中，我们简要总结了哺乳动物中的铁稳态，并讨论了在理解多种癌症类型中铁代谢异常方面的最新进展，重点是揭示癌细胞中信号转导改变的研究。
