Waldinger Marcel D, Zwinderman Aeilko H, Olivier Berend
Department of Psychiatry and Neurosexology, Leyenburg Hospital, The Hague, The Netherlands.
J Clin Psychopharmacol. 2003 Oct;23(5):467-70. doi: 10.1097/01.jcp.0000088904.24613.e4.
A double-blind, fixed-dose study in healthy men with lifelong early ejaculation was performed to evaluate potential differences in their effects on ejaculation latency, between clinically relevant doses of the selective serotonin reuptake inhibitor paroxetine and the noradrenergic and specific serotonergic antidepressant mirtazapine. Twenty-four men with an intravaginal ejaculation latency time (IELT) less than 1 minute were randomly assigned to paroxetine (20 mg/d) or mirtazapine (30 mg/d) for a period of 6 weeks; half the dosage was given in the first week. During the preceding 1-month baseline and 6-week treatment period, intravaginal ejaculation latency times were measured at home using a stopwatch procedure. The trial was completed by 18 men. Analysis of variance revealed a between-group difference in the development of the delay in intravaginal ejaculation latency time over time (P < 0.001); the intravaginal ejaculation latency time after paroxetine and mirtazapine gradually increased from 15 to 119 s and from 23 to 28 s, respectively, after 6 weeks. Paroxetine 20 mg/d exerted a strong delay (maximum 5.7-fold increase), whereas mirtazapine 30 mg/d did not delay ejaculation (0.9-fold increase). These results confirm earlier findings that paroxetine, but not mirtazapine, significantly delays orgasm and ejaculation in men with early ejaculation, whereas mirtazapine is devoid of any effect on it.
一项针对患有终身性早泄的健康男性的双盲、固定剂量研究，旨在评估选择性5-羟色胺再摄取抑制剂帕罗西汀和去甲肾上腺素能及特异性5-羟色胺能抗抑郁药米氮平在临床相关剂量下对射精潜伏期影响的潜在差异。24名阴道内射精潜伏期（IELT）小于1分钟的男性被随机分配至帕罗西汀组（20毫克/天）或米氮平组（30毫克/天），为期6周；第一周给予一半剂量。在之前1个月的基线期和6周的治疗期内，使用秒表在家中测量阴道内射精潜伏期。18名男性完成了试验。方差分析显示，随着时间推移，两组间阴道内射精潜伏期延迟的发展存在差异（P < 0.001）；6周后，帕罗西汀和米氮平治疗后的阴道内射精潜伏期分别从15秒逐渐增加至119秒和从23秒增加至28秒。20毫克/天的帕罗西汀产生了强烈的延迟作用（最大增加5.7倍），而30毫克/天的米氮平未延迟射精（增加0.9倍）。这些结果证实了早期的研究发现，即帕罗西汀而非米氮平能显著延迟早泄男性的性高潮和射精，而米氮平对此无任何作用。
