血压与特定部位癌症死亡率：来自白厅原始研究的证据。
Blood pressure and site-specific cancer mortality: evidence from the original Whitehall study.
作者信息
Batty G D, Shipley M J, Marmot M G, Davey Smith G
机构信息
Department of Social Medicine, Institute of Public Health, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark.
出版信息
Br J Cancer. 2003 Oct 6;89(7):1243-7. doi: 10.1038/sj.bjc.6601255.
Abstract
Studies relating blood pressure to cancer risk have some shortcomings and have revealed inconsistent findings. In 17498 middle-aged London-based government employees we related systolic and diastolic blood pressure recorded at baseline examination (1967-1970) to the risk of cancer mortality risk at 13 anatomical sites 25 years later. Following adjustment for potential confounding and mediating factors, inverse associations between blood pressure and mortality due to leukaemia and cancer of the pancreas (diastolic only) were seen. Blood pressure was also positively related to cancer of the liver and rectum (diastolic only). The statistically significant blood pressure-cancer associations seen in this large-scale prospective investigation offering high power were scarce and of sufficiently small magnitude as to be attributable to chance or confounding.
摘要
关于血压与癌症风险关系的研究存在一些缺陷，且结果并不一致。在17498名总部位于伦敦的中年政府雇员中，我们将基线检查（1967 - 1970年）时记录的收缩压和舒张压与25年后13个解剖部位的癌症死亡风险进行了关联分析。在对潜在的混杂因素和中介因素进行调整后，发现血压与白血病和胰腺癌（仅舒张压）导致的死亡率之间存在负相关。血压与肝癌和直肠癌（仅舒张压）也呈正相关。在这项具有高统计学效力的大规模前瞻性调查中，观察到的具有统计学意义的血压与癌症的关联很少，且关联程度足够小，可能是由于偶然因素或混杂因素所致。
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