Morimoto Shin-ichiro, Kubo Natsuko, Hiramitsu Shinya, Uemura Akihisa, Ohtsuki Masatsugu, Kato Shigeru, Kato Yasuchika, Sugiura Atsushi, Miyagishima Kenji, Mori Nami, Yoshida Yukihiko, Hishida Hitoshi
Division of Cardiology, Department of Internal Medicine, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan.
Heart Vessels. 2003 Sep;18(4):193-6. doi: 10.1007/s00380-003-0721-0.
In many cases, the diagnosis of eosinophilic myocarditis is suggested by an elevated peripheral blood eosinophil count. However, no detailed studies have been performed on the sequential changes in the initial peripheral blood eosinophil count over the course of the disease. We measured the peripheral blood eosinophil count at the time of presentation in eight patients with eosinophilic myocarditis proven by endomyocardial biopsy and intermittently thereafter. The eosinophil count at the time of onset was <500/mm(3) in four patients, >500/mm(3) but <1,000/mm(3) in three patients, and > or =1,000/mm(3) in one patient. In three of the four patients with an initial eosinophil count of <500/mm(3), an increase to > or =500/mm(3) occurred 7-12 days after the onset. The remaining patient did not develop peripheral eosinophilia. In conclusion, in the early stage of eosinophilic myocarditis, peripheral hypereosinophilia is not present initially in some patients, and may not develop during the course of the illness in a subset of these patients.
在许多情况下，外周血嗜酸性粒细胞计数升高提示嗜酸性粒细胞性心肌炎的诊断。然而，尚未对疾病过程中初始外周血嗜酸性粒细胞计数的连续变化进行详细研究。我们对8例经心内膜心肌活检证实为嗜酸性粒细胞性心肌炎的患者在就诊时及之后进行了外周血嗜酸性粒细胞计数的测定。发病时嗜酸性粒细胞计数，4例患者<500/mm³，3例患者>500/mm³但<1000/mm³，1例患者≥1000/mm³。4例初始嗜酸性粒细胞计数<500/mm³的患者中，有3例在发病7 - 12天后嗜酸性粒细胞计数增加至≥500/mm³。其余1例患者未出现外周嗜酸性粒细胞增多。总之，在嗜酸性粒细胞性心肌炎的早期，部分患者最初不存在外周嗜酸性粒细胞增多，且其中一部分患者在病程中可能不会出现外周嗜酸性粒细胞增多。
