Lackmann G M, Ndagijimana J, Niehues T
Reinstorfweg 10a, 21107 Hamburg.
Klin Padiatr. 2003 Sep-Oct;215(5):280-2. doi: 10.1055/s-2003-42663.
We report the case of an 8-year-old girl with skin eruptions on both hands that were thought to be of viral origin and, therefore, had been treated with an unspecific immunostimulating agent, containing large amounts of inosine. Under this therapy, which is - despite contrasting knowledge - still thought to be harmless and without serious side effects in the opinion of many physicians and especially medical laymen, the girl's condition worsened rapidly. Diagnosis of juvenile dermatomyositis was made. Because inosine is able to enhance T-cell proliferation and reverse immunosuppression in vitro, both mechanisms may have aggravated the disease course in our patient, once the autoimmune process of dermatomyositis has been initiated.
我们报告了一名8岁女孩的病例，她双手出现皮疹，最初认为是病毒感染所致，因此接受了一种含有大量肌苷的非特异性免疫刺激剂治疗。尽管有相反的认识，但许多医生尤其是外行仍认为这种治疗无害且无严重副作用。在此治疗下，女孩的病情迅速恶化。最终诊断为青少年皮肌炎。由于肌苷在体外能够增强T细胞增殖并逆转免疫抑制，一旦皮肌炎的自身免疫过程启动，这两种机制都可能加剧了我们这位患者的病程。
