Vinokurova N G, Boĭchenko L V, Arinbasarov M U
Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Pushchino, Moscow Oblast, 142290 Russia.
Prikl Biokhim Mikrobiol. 2003 Jul-Aug;39(4):457-60.
The ability to produce alkaloids has been studied in 13 strains belonging to 10 species of the genus Penicillium. Most of these strains produce identical ranges of alkaloids when grown on wheat grain and synthetic Abe medium. They are roquefortine, 3,12-dihydroroquefortine, and glandicolines A and B in strain P. chrysogenum VKM F-1987; fumigaclavines A and B, festuclavine, and pyroclasine in P. commune VKM F-308, F-3491, and KBP4; agroclavine 1 and epoxyagroclavine 1 in P. fellutanum VKM F-1073; fellutanine A in P. fellutanum F-3020; roquefortine, 3,12-dihydroroquefortine, meleagrin, and glandicolines A and B in P. glandicola VKM F-743; aurantioclavine in P. nalgiovense VKM F-229; isofumigaclavines A and B, festuclavine, roquefortine, and 3,12-dihydroroquefortine in P. roquefortii VKM F-2389; roquefortine, 3,12-dihydroroquefortine, and meleagrin in P. vitale VKM F-3624; roquefortine and oxaline in P. vulpinum VKM F-256; and alpha-cyclopiazonic acid and rugulovasine B in P. viridicatum C-47. No alkaloids were found in P. rugulosum VKM F-352 grown on wheat grain. A simple method is proposed for isolating alkaloids from affected grains.
对青霉属10个物种的13个菌株产生生物碱的能力进行了研究。这些菌株中的大多数在小麦籽粒和合成阿贝培养基上生长时，产生的生物碱范围相同。产黄青霉VKM F - 1987菌株产生的生物碱有棒曲霉素、3,12 - 二氢棒曲霉素以及A和B型麦角硫因；普通青霉VKM F - 308、F - 3491和KBP4菌株产生的生物碱有烟曲霉黄质A和B、费斯曲菌素以及焦曲霉毒素；费氏青霉VKM F - 1073菌株产生的生物碱有农吉利碱1和环氧农吉利碱1；费氏青霉F - 3020菌株产生的生物碱有费氏青霉碱A；格氏青霉VKM F - 743菌株产生的生物碱有棒曲霉素、3,12 - 二氢棒曲霉素、麦角硫因以及A和B型麦角硫因；纳氏青霉VKM F - 229菌株产生的生物碱有橙黄青霉碱；罗克福特青霉VKM F - 2389菌株产生的生物碱有异烟曲霉黄质A和B、费斯曲菌素、棒曲霉素以及3,12 - 二氢棒曲霉素；维氏青霉VKM F - 3624菌株产生的生物碱有棒曲霉素、3,12 - 二氢棒曲霉素以及麦角硫因；狐青霉VKM F - 256菌株产生的生物碱有棒曲霉素和草酸盐；绿青霉C - 47菌株产生的生物碱有α - 环匹阿尼酸和皱波角鲨素B。在小麦籽粒上生长的皱褶青霉VKM F - 352未发现生物碱。提出了一种从受影响的籽粒中分离生物碱的简单方法。
