Kozlovskiĭ A G, Zhelifonova V P, Adanin V M, Antipova T V, Szerskaia S M, Ivanushkina N E, Grafe U
Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Pushchino, Moscow Oblast, 142290 Russia.
Prikl Biokhim Mikrobiol. 2003 Jul-Aug;39(4):446-51.
Secondary metabolites of the three strains of Penicillium aurantiogriseum, isolated from permafrost sediments, were identified. It was found that these fungi synthesized diketopiperazine alkaloids roquefortine and 3,12-dihydroroquefortine. The strain VKM FW-766 synthesized alkaloids in in the course of certain growth-related processes. When the strain was grown on a mineral medium, time courses of roquefortine and 3,12-dihydroroquefortine concentrations were characterized by biphasic curves.
对从永久冻土沉积物中分离出的三株橙灰青霉的次生代谢产物进行了鉴定。发现这些真菌合成了二酮哌嗪生物碱罗克福汀和3,12 - 二氢罗克福汀。菌株VKM FW - 766在某些与生长相关的过程中合成生物碱。当该菌株在矿物培养基上生长时，罗克福汀和3,12 - 二氢罗克福汀浓度的时间进程呈现双相曲线特征。
