Zhou Z, Lan T, Zha Z, Wang Y, Yang Z
Department of Physiology.
Hua Xi Yi Ke Da Xue Xue Bao. 1991 Jun;22(2):137-9.
The purpose of this study was to investigate the influences of vesnarinone, newly synthesized in the School of Pharmacy, West China University of Medical Sciences in 1985, on the circulatory and respiratory functions of dogs. Eight dogs were anesthetized with 3% sodium pentobarbital. Vesnarinone (2 mg/kg), dimethyl sulphoxide (the solvent which was needed to prepare solution of OPC-8212), and 0.9% NaCl (normal control) was given separately according to the arrangement of Latin square. The ECG, blood flow, blood pressure and respiration were measured and recorded for 1-15 minutes. Vesnarinone increased the blood flow in the common carotid artery with no significant changes in blood pressure, heart rate, or respiration. These results suggest that OPC-8212 has positive inotropic effect but no effect on the heart rate in anesthetized dogs.
本研究的目的是探讨1985年由华西医科大学药学院新合成的维司力农对犬循环和呼吸功能的影响。8只犬用3%戊巴比妥钠麻醉。按照拉丁方安排分别给予维司力农（2mg/kg）、二甲基亚砜（制备OPC-8212溶液所需的溶剂）和0.9%氯化钠（正常对照）。测量并记录1至15分钟内的心电图、血流量、血压和呼吸情况。维司力农可增加颈总动脉血流量，而血压、心率或呼吸无明显变化。这些结果表明，OPC-8212对麻醉犬有正性肌力作用，但对心率无影响。
